Difference between revisions of "DZI19-36-Case-1"

Latest revision as of 15:06, March 9, 2022

UMass: Unusual B- and T-cell Lymphoproliferative Disorders • (DZI19-36)

Clinical

64-year-old woman with history of lupus on methotrexate, with prominent bilateral cervical and axillary lymphadenopathy (biopsy is of enlarged right axillary lymph node). Serum and urine protein and immunofixation electrophoresis showed abnormal banding (images of gels provided).

Diagnosis

Gamma heavy chain disease

References

Hamadeh F, et al. Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma. Haematologica 2014;99:e154-5. PubMed ID:24859878
Bianchi G, et al. The heavy chain diseases: clinical and pathologic features. Oncology (Williston Park) 2014;28:45-53. PubMed ID:24683718
Bieliauskas S, et al. Gamma heavy-chain disease: defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. Am J Surg Pathol 2012;36:534-43. PubMed ID:22301495

Additional files

SPEP

Slide: 1

Stain: H&E • File: DZI19-36-Case-1_1

UMass: Unusual B- and T-cell Lymphoproliferative Disorders • Dr. Sohani

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