DZI19-36: Case 2

UMass: Unusual B- and T-cell Lymphoproliferative Disorders • (DZI19-36)

Clinical

41-year-old HIV+ man with anemia, fevers, hepatosplenomegaly and generalized lymphadenopathy.

Diagnosis

Castleman disease, plasmablastic variant, consistent with HHV8+ multicentric Castleman disease

References

• Du MQ, et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood 2001;97:2130-6. PubMed ID:11264181

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UMass: Unusual B- and T-cell Lymphoproliferative Disorders • Dr. Sohani

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