WSI21-141: Bone and Soft Tissue
From MGH Learn Pathology
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Toggle columns: Diagnosis
| Case | Clinical history | Requester | Diagnosis |
|---|---|---|---|
| Case | Clinical history | Requester | Diagnosis |
|
| 56-year-old male • neck mass. | Iac0 | Schwannoma |
|
| 68yo female with right foot pain/swelling around 2nd metatarsal x 2 months | Mlz8 | Gout tophus (collections of monosodium urate crystals and foreign body giant cells) |
|
| 70yo male with sacral mass | Mlz8 | Chordoma |
|
| 19 year-old-male. Pubic bone mass. Renal mass. Family history of cutaneous leiomyomas. | Iac0 | Metastatic papillary renal cell carcinoma • type 2. Likely hereditary leiomyomatosis and renal cell cancer syndrome. |
|
| 51F. Left masticator space. | Iac0 | Tenosynovial giant cell tumor. |
|
| 31 F. Hx of rhabdomyosarcoma. Mediastinal lymphadenopathy. | Iac0 | Metastatic rhabdomyosarcoma. |
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| 78 y/old M with prior excised tumor in the head/ear | Aja51 | Melanoma with spindle cell morphology. |
|
| 74-year-old female with an ill-defined 6.7cm mass in the gastrosplenic ligament | Sj82 | Gastrointestinal stromal tumor (GIST) |
|
| 77 year old woman with a scalp nodule and a history of a sacral mass. | Cfh13 | Metastatic chondrosarcoma • conventional type. |
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| 50F. History of leiomyosarcoma. | Iac0 | Metastatic leiomyosarcoma. |
|
| 52 yo male with a 2 week history of jaw mass with fevers • night sweats • and possible weight loss. 0.4 cm firm fixed mass. | Ndk6 | Diffuse large B-cell lymphoma |
|
| 86 yo female with a history of squamous cell carcinoma of right calf. Now presents with a large mass in the inner upper thigh/groin • which has a necrotic center. | Ndk6 | Squamous cell carcinoma |
|
| 27F. Hx of Ewing sarcoma | Iac0 | Metastatic Ewing sarcoma. |
|
| 31M with mediastinal mass | Mlz8 | Ganglioneuroma |
|
| 41 YO female with h/o undifferentiated carcinoma and new pelvic soft tissue mass | Ndk6 | Undifferentiated pleomorphic malignant neoplasm |
|
| 43M. Multiple lung nodules consistent with metastasis. No known primary. | Iac0 | Metastatic extraskeletal myxoid chondrosarcoma • with EWSR1::NR4A3. |
|
| 50F. Left pelvis. Parathyroid adenoma | Iac0 | Giant cell rich lesion. In correlation with clinical history • consistent with Brown tumor. |
|
| 46F. Left elbow mass. | Iac0 | Tenosynovial giant cell tumor (giant cell tumor of tendon sheath) |
|
| 77M. Lung mass. History of solitary fibrous tumor. | Iac0 | Metastatic solitary fibrous tumor. |
|
| 3M. Paraspinal mass. | Iac0 | Neuroblastoma |
|
| 49F. Right cheek mass. | Iac0 | Foreign body giant cell reaction to mucoid material • most consistent with dermal fillers. |
|
| 63F. Left hilar lung mass. | Iac0 | Cytology dx: Epithelioid neoplasm with myxoid matrix. EWSR1 FISH and fusion assay on cell block were negative for reportable fusions. Resection dx: SMARCB1-deficient neoplasm most consistent with malignant myoepithelioma. |
|
| 84 YO male with peri-stomal mass | Ndk6 | Chondrosarcoma |
|
| 43 YO male with enlarged lymph node and neck mass | Ndk6 | Metastatic chordoma • conventional type |
|
| 43M. History of chordoma. | Iac0 | Metastatic chordoma. |
|
| 74F. Pleural biopsy. | Iac0 | Solitary fibrous tumor. |
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| 50M. Chest wall mass. | Iac0 | Low-grade leiomyosarcoma. |
|
| 36 year old male. Cheek. | Iac0 | Granular cell tumor. |
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| 53 yo F with incidental 8.8 cm fluid-attenuating lesion arising from the aponeurosis of the external abdominal oblique muscle. Dark brown cyst contents on aspiration. Remainder of history unremarkable. | Dl292 | Clear cell carcinoma • likely arising in background endometriosis |
|
| 72M. Lung squamous cell carcinoma. Now with right temporalis muscle mass. On imaging • the tumor involving the right pterional calvarium and pachymeninges. | Iac0 | Meningioma. |
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| 53M. History of atypical ossifying fibromxyoid tumor of chest wall. | Iac0 | Metastatic malignant ossifying fibromyxoid tumor. |
|
| 71M. Chest wall mass. | Iac0 | High-grade sarcoma • consistent with dedifferentiated liposarcoma (MDM2 amplification confirmed on surgical pathology). |
|
| 25 yo M with h/o metastatic alveolar rhabdomyosarcoma (PAX3::FOXO1 fusion) to prostate and retroperitoneal lymph nodes. Now presents with a 2.1 cm subcutaneous mass on left chest. | Tz046 | Metastatic alveolar rhabdomyosarcoma. |
|
| 52M. 4.5 cm R TMJ mass. | Iac0 | Tenosynovial giant cell tumor. |
|
| 40M. Hx of myxoinflammatory fibroblastic sarcoma of left arm. Now with mass proximal to prior resection. | Iac0 | Recurrent myxoinflammatory fibroblastic sarcoma. |
|
| 84-year-old man with right neck cystic nodule | Lt511 | organizing abscess with numerous multinucleated giant cells |
|
| 83F. Cheek mass. | Iac0 | Merkel cell carcinoma. |
|
| 27F. History of alveolar rhabdomyosarcoma. Bone marrow biopsy. | Iac0 | Metastatic alveolar rhabdomyosarcoma. |
