WSI21-141

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Request type Study

Subspecialty Cytology

Set Cytology

Topic Bone and Soft Tissue

Presenter MGH

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Toggle columns: Diagnosis

Case	Clinical history	Requester	Diagnosis
Case	Clinical history	Requester	Diagnosis
Case 1	56-year-old male • neck mass.	Iac0	Schwannoma
Case 2	68yo female with right foot pain/swelling around 2nd metatarsal x 2 months	Mlz8	Gout tophus (collections of monosodium urate crystals and foreign body giant cells)
Case 3	70yo male with sacral mass	Mlz8	Chordoma
Case 4	19 year-old-male. Pubic bone mass. Renal mass. Family history of cutaneous leiomyomas.	Iac0	Metastatic papillary renal cell carcinoma • type 2. Likely hereditary leiomyomatosis and renal cell cancer syndrome.
Case 5	51F. Left masticator space.	Iac0	Tenosynovial giant cell tumor.
Case 6	31 F. Hx of rhabdomyosarcoma. Mediastinal lymphadenopathy.	Iac0	Metastatic rhabdomyosarcoma.
Case 7	78 y/old M with prior excised tumor in the head/ear	Aja51	Melanoma with spindle cell morphology.
Case 8	74-year-old female with an ill-defined 6.7cm mass in the gastrosplenic ligament	Sj82	Gastrointestinal stromal tumor (GIST)
Case 9	77 year old woman with a scalp nodule and a history of a sacral mass.	Cfh13	Metastatic chondrosarcoma • conventional type.
Case 10	50F. History of leiomyosarcoma.	Iac0	Metastatic leiomyosarcoma.
Case 11	52 yo male with a 2 week history of jaw mass with fevers • night sweats • and possible weight loss. 0.4 cm firm fixed mass.	Ndk6	Diffuse large B-cell lymphoma
Case 12	86 yo female with a history of squamous cell carcinoma of right calf. Now presents with a large mass in the inner upper thigh/groin • which has a necrotic center.	Ndk6	Squamous cell carcinoma
Case 13	27F. Hx of Ewing sarcoma	Iac0	Metastatic Ewing sarcoma.
Case 14	31M with mediastinal mass	Mlz8	Ganglioneuroma
Case 15	41 YO female with h/o undifferentiated carcinoma and new pelvic soft tissue mass	Ndk6	Undifferentiated pleomorphic malignant neoplasm
Case 16	43M. Multiple lung nodules consistent with metastasis. No known primary.	Iac0	Metastatic extraskeletal myxoid chondrosarcoma • with EWSR1::NR4A3.
Case 17	50F. Left pelvis. Parathyroid adenoma	Iac0	Giant cell rich lesion. In correlation with clinical history • consistent with Brown tumor.
Case 18	46F. Left elbow mass.	Iac0	Tenosynovial giant cell tumor (giant cell tumor of tendon sheath)
Case 19	77M. Lung mass. History of solitary fibrous tumor.	Iac0	Metastatic solitary fibrous tumor.
Case 20	3M. Paraspinal mass.	Iac0	Neuroblastoma
Case 21	49F. Right cheek mass.	Iac0	Foreign body giant cell reaction to mucoid material • most consistent with dermal fillers.
Case 22	63F. Left hilar lung mass.	Iac0	Cytology dx: Epithelioid neoplasm with myxoid matrix. EWSR1 FISH and fusion assay on cell block were negative for reportable fusions. Resection dx: SMARCB1-deficient neoplasm most consistent with malignant myoepithelioma.
Case 23	84 YO male with peri-stomal mass	Ndk6	Chondrosarcoma
Case 24	43 YO male with enlarged lymph node and neck mass	Ndk6	Metastatic chordoma • conventional type
Case 25	43M. History of chordoma.	Iac0	Metastatic chordoma.
Case 26	74F. Pleural biopsy.	Iac0	Solitary fibrous tumor.
Case 27	50M. Chest wall mass.	Iac0	Low-grade leiomyosarcoma.
Case 28	36 year old male. Cheek.	Iac0	Granular cell tumor.
Case 29	53 yo F with incidental 8.8 cm fluid-attenuating lesion arising from the aponeurosis of the external abdominal oblique muscle. Dark brown cyst contents on aspiration. Remainder of history unremarkable.	Dl292	Clear cell carcinoma • likely arising in background endometriosis
Case 30	72M. Lung squamous cell carcinoma. Now with right temporalis muscle mass. On imaging • the tumor involving the right pterional calvarium and pachymeninges.	Iac0	Meningioma.
Case 31	53M. History of atypical ossifying fibromxyoid tumor of chest wall.	Iac0	Metastatic malignant ossifying fibromyxoid tumor.
Case 32	71M. Chest wall mass.	Iac0	High-grade sarcoma • consistent with dedifferentiated liposarcoma (MDM2 amplification confirmed on surgical pathology).
Case 33	25 yo M with h/o metastatic alveolar rhabdomyosarcoma (PAX3::FOXO1 fusion) to prostate and retroperitoneal lymph nodes. Now presents with a 2.1 cm subcutaneous mass on left chest.	Tz046	Metastatic alveolar rhabdomyosarcoma.
Case 34	52M. 4.5 cm R TMJ mass.	Iac0	Tenosynovial giant cell tumor.
Case 35	40M. Hx of myxoinflammatory fibroblastic sarcoma of left arm. Now with mass proximal to prior resection.	Iac0	Recurrent myxoinflammatory fibroblastic sarcoma.
Case 36	84-year-old man with right neck cystic nodule	Lt511	organizing abscess with numerous multinucleated giant cells
Case 37	83F. Cheek mass.	Iac0	Merkel cell carcinoma.
Case 38	27F. History of alveolar rhabdomyosarcoma. Bone marrow biopsy.	Iac0	Metastatic alveolar rhabdomyosarcoma.