WSI23-41

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Request type Study

Subspecialty Genitourinary

Set Genitourinary

Topic Prostate

Presenter Sadow, Peter M.,MD, PhD

Date and time Saturday, April 1, 2023 12:00 PM

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Case	Clinical history	Requester	Diagnosis
Case	Clinical history	Requester	Diagnosis
Case 1	84 year old male with bladder outlet obstruction • TURP	Si787	High grade prosttic adenocrcinoma • gleason score 5 of 5 with neuroendocrine differentiation
Case 2	71 year old male with history of prostate cancer s/p prostatectomy and radiation in 2010 • now with S2 spinal lesion	Si787	Metastatic prostatic adenocarcinoma
Case 3	61 year old with prostate cancer	Si787	Adenocarcinoma • gleason score 3+3=6/10 • bilateral perineural invasion • neg margins • neg SV and vas def
Case 4	86 year old male with hard nodular prostate and PSA 175	Si787	Prostatic adenocarcinoma • gleason score 5+4=9/10 • involving >90% each of 2/2 cores. + PNI tumor invades skeletal muscle and adipose tissue. Sheet-like growth & foamy cell and signet ring-like changes
Case 5	62 year old man with radical prostatectomy revealing 3+3=6/10 cancer. Here is a separate finding.	Si787	Senile amyloid of bilateral seminal vesicles
Case 6	58 year old male with elevated PSA.	Si787	Prostatic adenocarcinoma 3+4=7/10 with mucinous differentiation +PNI
Case 7	65 year old male with ↑ PSA with negative biopsy in 2011 • now for TURP 2° to urinary retention symptoms PSA in 2011 • 5 ng/mL; post biopsy 10 ng/ml	Si787	Prostatic adenocarcinoma • gleason score 4+5=9/10 with perineural invasion • infiltrating skeletal muscle
Case 8	60 year old male with prostate cancer	Si787	A. Grade 5 prostate carcinoma with PNI in bladder neck. B. 5+4 with EPE • PN1 • LVI
Case 9	80 year old male with history of BPH s/p TURP 2008; 2009 with palp nodule on right lateral prostate	Si787	Prostate adenocarcinoma 4+4 with focal ductal-type features
Case 10	57 year old man with urinary outlet obstruction and mildly elevated PSA • 4.88 (11/08) over prior 3.69 (5/08)	Si787	Adenocarcinoma • ductal type • gleason score 4+4=8/10.
Case 11	76 year old male with elevated PSA.	Si787	A. Adenocarcinoma 4+4 ? Seminal vesicle. B. Adenocarcinoma 4+5 with fat infiltration.
Case 12	89 year old male with h/o prostate cancer in 1998 (11 yr) on active surveilance with increasing PSA and subsequent papillary TCC • non-invasive. He now has outlet obstruction. TURP.	Si787	Poorly differentiated TCC • grade 3 of 3. +CK7 • +p63. PSA & PSAP+ in uninvolved prostate
Case 13	71 year old male with prostate cancer • 3+3=6/10 on core biopsy.	Emw8	Prostatic adenocarcinoma • Gleason score 4+3=7/10 • bilateral with bilateral seminal vesicle involvement • extraprostatic extension and lymphovascular invasion.
Case 14	66 year old male with elevated PSA and core biopsies.	Emw8	Prostatic adenocarcinoma 3+3=6/10 • involving 20% of right-sided cores (B). A&C negative by immunostain (outside called PIN • not here).