WSI21-136

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Request type Study

Subspecialty Cytology

Set Cytology

Topic Cerebrospinal Fluid

Presenter MGH

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Toggle columns: Diagnosis

Case	Clinical history	Requester	Diagnosis
Case	Clinical history	Requester	Diagnosis
Case 1	74-year-old female. History of metastatic breast carcinoma and ventricular shunt placement.	Iac0	Brain parenchyma.
Case 2	67yo F w/history of metastatic lung adenocarcinoma	Mlz8	Metastatic adenocarcinoma
Case 3	59 year old man with multiple sclerosis on high dose dexamethasone	Lz17	Fungal forms consistent with Cryptococcus neoformans. Narrow based budding yeast (do not mistake for RBCs).
Case 4	66 year old M with history of a spine cord lesion and suspicion for Lyme's disease	Lcm51	Lyme's disease pleocytosis
Case 5	67 year old male with mental status changes and ring enhancing lesions in the parietal lobe.	Cfh13	No malignant cells identified. Cryptococcus.
Case 6	76 year-old man with a history of CLL and symptoms concerning for new CNS involvement.	Cfh13	Positive for malignant cells with clonal B cell population on flow cytometry. Clonal B cell population and large malignant cells of unclear etiology. Concurrent surgical specimen: DLBCL consistent with Richter's transformation of patient's known CLL.
Case 7	66 yo F with a history of high grade B cell lymphoma.	Cfh13	No malignant cells identified. Chondrocytes.
Case 8	25 yo M with a history of medulloblastoma status post resection.	Cfh13	Poorly differentiated round cell malignancy. IHC on subsequent biopsy confirmed recurrent/residual medulloblastoma.
Case 9	37 yo woman with a history of melanoma	Cfh13	Metastatic melanoma.
Case 10	65 yo F with NSCLC	Ndk6	Adenocarcinoma • consistent with metastasis from patient's known lung primary.
Case 11	67 yo M with known metastatic prostate cancer	Ndk6	Metastatic adenocarcinoma • cytomorphologically consistent with the patient’s known prostate primary
Case 12	59 yo M with a history of AML	Ndk6	Blasts present • consistent with involvement by the patient's known leukemia.
Case 13	48 yo M with a history of adenocarcinoma • lung primary.	Ndk6	Metastatic adenocarcinoma
Case 14	74yo F with history of lung cancer who presents with acute and chronic intractable nausea and vomiting	Ndk6	Adenocarcinoma • consistent with metastasis of the patient's known lung primary.
Case 15	66 yo M with a history of transformed follicular lymphoma and CAR-T on trial.	Ndk6	Positive for malignancy • c/w patient's know transformed follicular lymphoma
Case 16	57 yo M with a history mantle cell lymphoma and known CNS involvement.	Ndk6	Positive for malignant cells • compatible with involvement by mantle cell lymphoma
Case 17	57 year old male with history of GBM	Ndk6	Malignant neoplasm • consistent with patient’s known glioblastoma
Case 18	69 YO F with history of B cell lymphoma	Ndk6	Negative for Malignancy- Abundant acute inflammation • rare lymphocytes and monocytes
Case 19	49 yo F with altered mental status • convulsions • and history of high grade serous carcinoma	Ndk6	POSITIVE FOR MALIGNANT CELLS- Adenocarcinoma with focally micropapillary and signet ring cell morphology.
Case 139	54 yo F with metastatic breast cancer • leptomeningeal disease suspected	Ndk6	Carcinoma • consistent with metastasis from patient's known high-grade breast cancer
Case 140	74-year-old man with lytic bone lesions	Lt511	Plasma cell neoplasm
Case 141	48F with met pancreas cancer with ?LMD	Ndk6	Metastatic adenocarcinoma
Case 142	76 yo F history of metastatic lung adenocarcinoma • now presenting with new CNS involvement	Ndk6	Metastatic adenocarcinoma