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Clinical history
33 year old diagnosed with papillary thyroid carcinoma in 2012. Lesion was a 2.0 cm in the right lobe with minimal extrathyroidal extension and two negative lymph nodes (currently would have been classified as pT1b N0a -- then pT3 N0). All was fine until July 2020 noted to have LUL lung lesion excised and RUL lung lesion excised Aug 2020. Jan 2021, noted to have two brain lesions (L frontoparietal and R occipital). Tumor noted to have CCDC149-ALK fusion. Subsequently treated with SAS (stereotactic ablative surgery -- gamma knife). Now alectinib.
Diagnosis
Kinase fusion-related thyroid carcinoma (for now, associated with classical papillary thyroid carcinoma). Alectinib targets ALK (anaplastic lymphoma kinase)
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