WSI23-88: Practical Cases – Head & Neck Pathology
From MGH Learn Pathology
Request details
- Request type Study
- Subspecialty Head and Neck
- Set Current Concepts in Head and Neck and Endocrine Pathology
- Topic Practical Cases – Head & Neck Pathology
- Presenter Faquin, William C.,MD, PhD
- Date and time Friday, June 9, 2023 5:00 AM
Toggle columns: Diagnosis
| Case | Clinical history | Requester | Diagnosis |
|---|---|---|---|
| Case | Clinical history | Requester | Diagnosis |
|
| 20 year old female with floor of mouth tumor. | Kx601 | Adamantinoma-like Ewing's sarcoma. (FISH is + for EWSR fusion) |
|
| 67 year old male with left maxillary sinus cancer. | Kx601 | NUT carcinoma |
|
| 74 year old female with chronic otitis media and middle ear mass. | Kx601 | Phosphaturic mesenchymal tumor. |
|
| 38 year old woman with mass adjacent to/adherent to thyroid gland. | Kx601 | Parathyroid carcinoma (1.2 cm) • with tumor infiltrating thyroid gland and suspicious for lymphovascular invasion. |
|
| 70 year old female with a mass arising in the sinonasal tract. | Kx601 | SWI/SNF complex-deficient sinonasal carcinoma with SMARCB1 loss. |
|
| 55 year old man with a one year of nasal congestion • epistaxis and drainage • and a large mass in the right nasal cavity | Kx601 | HPV-related multiphenotypic sinonasal carcinoma • previously called HPV-related adenoic cystic-like carcinoma |
|
| 82 year old male with left parotid mass. | Kx601 | Metastatic renal cell carcinoma. |
|
| 33 year old diagnosed with papillary thyroid carcinoma in 2012. Lesion was a 2.0 cm in the right lobe with minimal extrathyroidal extension and two negative lymph nodes (currently would have been classified as pT1b N0a -- then pT3 N0). All was fine until July 2020 noted to have LUL lung lesion excised and RUL lung lesion excised Aug 2020. Jan 2021 • noted to have two brain lesions (L frontoparietal and R occipital). Tumor noted to have CCDC149-ALK fusion. Subsequently treated with SAS (stereotactic ablative surgery -- gamma knife). Now alectinib. | Kx601 | Kinase fusion-related thyroid carcinoma (for now • associated with classical papillary thyroid carcinoma). Alectinib targets ALK (anaplastic lymphoma kinase) |
|
| 21 year old man with presents with changes in phonation and a multifocal thyroid masses | Kx601 | fusion kinase-related papillary thyroid carcinoma • multifocal (up to 2.9 cm) with extrathyroidal extension and neural involvement and extensive lateral neck mets. Grossly involving recurrent laryngeal nerve and ligament of Berry (pT4a). Positive for NCOA-RET fusion; selpercatinib (RET inhibitor) pre and post-operatively |
