WSI23-33-Case-18

Sequence	Case	Clinical history	Diagnosis
1	WSI23-33-Case-1 WSI23-33-Case-1	A 9-year-old girl presented with headaches and was seen to have a large tumor at the craniovertebral junction. The tumor is diffusely positive for keratin. What other stain(s) would you do? A 9-year-old girl presented with headaches and was seen to have a large tumor at the craniovertebral junction. The tumor is diffusely positive for keratin. What other stain(s) would you do?	Poorly differentiated chordoma. Poorly differentiated chordoma.
2	WSI23-33-Case-2 WSI23-33-Case-2	A young woman presented with upper arm pain and was found to have a mineralized tumor arising from the surface of the proximal humerus. An unusual case that was confirmed after the translocation results. What do you think they showed? A young woman presented with upper arm pain and was found to have a mineralized tumor arising from the surface of the proximal humerus. An unusual case that was confirmed after the translocation results. What do you think they showed?	Parosteal myositis ossificans. Parosteal myositis ossificans.
3	WSI23-33-Case-3 WSI23-33-Case-3	A young patient presented with a rapidly growing soft tissue mass of the forearm. Does this tumor have any genetic similarities to the previous case (case 2)? A young patient presented with a rapidly growing soft tissue mass of the forearm. Does this tumor have any genetic similarities to the previous case (case 2)?	Nodular fasciitis.
4	WSI23-33-Case-4 WSI23-33-Case-4	A 35-year-old man complained of knee pain and was found to have a mineralized mass arising from the posterior distal aspect of the femur. What diagnosis do you favor, and is there any stain or genetic study that might be helpful? A 35-year-old man complained of knee pain and was found to have a mineralized mass arising from the posterior distal aspect of the femur. What diagnosis do you favor, and is there any stain or genetic study that might be helpful?	Dedifferentiated parosteal osteosarcoma. Dedifferentiated parosteal osteosarcoma.
5	WSI23-33-Case-5 WSI23-33-Case-5	A 27-year-old female with a history of a carcinoid tumor of the lung now presents with a shoulder mass that has been present 'for years'. Is this tumor related to the carcinoid tumor? A 27-year-old female with a history of a carcinoid tumor of the lung now presents with a shoulder mass that has been present 'for years'. Is this tumor related to the carcinoid tumor?	Ewing sarcoma
6	WSI23-33-Case-6 WSI23-33-Case-6	A 57-year-old male presented with upper arm pain and was found to have a destructive lesion arising in the humerus, causing a pathologic fracture. How would you work this tumor? Given the diagnosis, is there anything unusual about his presentation? A 57-year-old male presented with upper arm pain and was found to have a destructive lesion arising in the humerus, causing a pathologic fracture. How would you work this tumor? Given the diagnosis, is there anything unusual about his presentation?	CIC sarcoma
7	WSI23-33-Case-7 WSI23-33-Case-7	A 34-year-old male presented with constitutional symptoms and a supraclavicular mass. Immunohistochemical stains showed positive staining for keratin (MNF 116), CD56, and synaptophysin. There was no staining for chromogranin or INSM1. The diagnosis of metastatic neuroendocrine carcinoma was favored, but then the translocation assay came back. A 34-year-old male presented with constitutional symptoms and a supraclavicular mass. Immunohistochemical stains showed positive staining for keratin (MNF 116), CD56, and synaptophysin. There was no staining for chromogranin or INSM1. The diagnosis of metastatic neuroendocrine carcinoma was favored, but then the translocation assay came back.	EWSR1-WT1 fusion sarcoma EWSR1-WT1 fusion sarcoma
8	WSI23-33-Case-8 WSI23-33-Case-8	A 49-year-old man presented with a thigh mass that was biopsied and resected. What is the differential diagnosis and other any particular stains that you would like to order? A 49-year-old man presented with a thigh mass that was biopsied and resected. What is the differential diagnosis and other any particular stains that you would like to order?	Lipoblastoma.
9	WSI23-33-Case-9 WSI23-33-Case-9	This is a mediastinal mass in a 54-year-old female with a history of breast cancer and ovarian carcinoma. What is the diagnosis, and can this tumor be associated with any particular syndrome? This is a mediastinal mass in a 54-year-old female with a history of breast cancer and ovarian carcinoma. What is the diagnosis, and can this tumor be associated with any particular syndrome?	Diagnosis
10	WSI23-33-Case-10 WSI23-33-Case-10	A 33-year-old man complained of shoulder pain and was found to have a lesion involving the proximal humerus. Are there any stains that might be helpful in diagnosing this tumor? A 33-year-old man complained of shoulder pain and was found to have a lesion involving the proximal humerus. Are there any stains that might be helpful in diagnosing this tumor?	Clear cell chondrosarcoma. Clear cell chondrosarcoma.

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