WSI23-33: Teaching set
From MGH Learn Pathology
Request details
- Request type Faculty
- Subspecialty Bone and Soft Tissue
- Topic Teaching set
- Presenter Nielsen, Gunnlaugur P.,MD
- Date and time Tuesday, March 28, 2023 12:00 AM
| Case | Clinical history | Requester |
|---|---|---|
| Case | Clinical history | Requester |
|
| A 9-year-old girl presented with headaches and was seen to have a large tumor at the craniovertebral junction. The tumor is diffusely positive for keratin. What other stain(s) would you do? | Aja51 |
|
| A young woman presented with upper arm pain and was found to have a mineralized tumor arising from the surface of the proximal humerus. An unusual case that was confirmed after the translocation results. What do you think they showed? | Aja51 |
|
| A young patient presented with a rapidly growing soft tissue mass of the forearm. Does this tumor have any genetic similarities to the previous case (case 2)? | Aja51 |
|
| A 35-year-old man complained of knee pain and was found to have a mineralized mass arising from the posterior distal aspect of the femur. What diagnosis do you favor • and is there any stain or genetic study that might be helpful? | Aja51 |
|
| A 27-year-old female with a history of a carcinoid tumor of the lung now presents with a shoulder mass that has been present 'for years'. Is this tumor related to the carcinoid tumor? | Aja51 |
|
| A 57-year-old male presented with upper arm pain and was found to have a destructive lesion arising in the humerus • causing a pathologic fracture. How would you work this tumor? Given the diagnosis • is there anything unusual about his presentation? | Aja51 |
|
| A 34-year-old male presented with constitutional symptoms and a supraclavicular mass. Immunohistochemical stains showed positive staining for keratin (MNF 116) • CD56 • and synaptophysin. There was no staining for chromogranin or INSM1. The diagnosis of metastatic neuroendocrine carcinoma was favored • but then the translocation assay came back. | Aja51 |
|
| A 49-year-old man presented with a thigh mass that was biopsied and resected. What is the differential diagnosis and other any particular stains that you would like to order? | Aja51 |
|
| This is a mediastinal mass in a 54-year-old female with a history of breast cancer and ovarian carcinoma. What is the diagnosis • and can this tumor be associated with any particular syndrome? | Aja51 |
|
| A 33-year-old man complained of shoulder pain and was found to have a lesion involving the proximal humerus. Are there any stains that might be helpful in diagnosing this tumor? | Aja51 |
|
| A 27-year-old female complaint of hip pain was found to have a lesion involving the femoral neck.
What is the diagnosis • and is any staining that could confirm the diagnosis? What is unusual about the radiographic findings? | Aja51 |
|
| A 60-year-old male with a tumor of the thoracic spine.
What diagnosis to favor? Is there any staining that can confirm the diagnosis? What are the two unusual aspects of this case? | Aja51 |
|
| A 71-year-old female with a history of breast carcinoma presented with a chest wall mass.
What are two important questions to ask? What is the differential diagnosis • and what stain might help diagnose this tumor? | Aja51 |
|
| A 46-year-old man had a total hip replacement for osteoarthritis. What is the diagnosis • and what is the primary defect in this disease? | Aja51 |
|
| A 46-year-old man presented with bilateral femoral fractures.
What is your diagnosis by slight reading alone? Does not fit with the radiographic findings? | Aja51 |
|
| A 73-year-old female with a recurrent tumor involving the temporomandibular joint. The original diagnosis was synovial chondromatosis. Do you agree with the diagnosis? | Aja51 |
|
| A 24-year-old male presented with foot pain and was found to have a tumor involving the fourth metacarpal bone. What three stains would you like to order to confirm the diagnosis? | Aja51 |
|
| A 46-year-old man presented with a shoulder lesion.
This controversial tumor is not included in the WHO classification of soft tissue tumors. What is your diagnosis? | Aja51 |
