WSI22-143: Salivary

From MGH Learn Pathology


Request type Study
Subspecialty Head and Neck
Set ENT Pathology
Topic Salivary
Presenter Sadow, Peter M.,MD, PhD
Date and time Saturday, October 1, 2022 12:00 PM


Toggle columns: Diagnosis

Case Clinical history Requester Diagnosis
Case Clinical history Requester Diagnosis

Case 1


60 year old female with left middle fossa CSF leak Si787 Meningoencephalocele

Case 2


43 year old female: biopsy of minor salivary tissue of lip Si787 Focus score = 6. c/w Sjogren syndrome

Case 3


88 year old retired surgeon with right temple Mohs now with parotid mass Si787 Metastatic SCC high grade with large vessel invasion and PNI & + margin

Case 4


63 year old male with parotid tumor Si787 c/w myoepithelial carcinoma intermediate grade (1.8 cm) completely excised

Case 5


45 year old female with left parotid mass noted 2 wks prior. Asymptomatic noted by a friend Si787 Acinic cell carcinoma with ductal and neuroendocrine features (4.8 cm) completely excised

Case 6


61 year old man with several years history of non-growing parotid mass recently painful Si787 Oncocytic carcinoma low grade with perineural invasion

Case 7


61 year old male with parotid mass Si787 Salivary duct carcinoma with high grade sarcomatoid transformation

Case 8


57 year old male presenting with slowly growing mass in the left parotid found to be a pleomorphic adenoma on FNA Si787 Carcinoma ex-pleomorphic adenoma. Mucoepidermoid carcinoma arising in a PA. Negative margins

Case 9


53 year old female with slow-growing submandibular mass for more than a year Si787 Low grade oncocytic cystic salivary neoplasm (1.1cm) most compatible with a mucoepidermoid carcinoma (MAML2 translocation)

Case 10


64 year old male with left parotid mass Si787 Low-grade lumphoepithelial lesion with features suggestive of Warthin tumor with metaplastic features. 1.7 cm

Case 11


17 year old female with "bump" in hard palate for several year adjacent to tooth #14 Si787 Acinic cell carcinoma microcystic pattern (0.45 cm) 0.1 cm from deep margin

Case 12


59 year old male with remote history of melanoma. Adenopathy on the right neck Si787 Adenoid cystic carcinoma In a right submandibular gland with dedifferentiation to high grade carcinoma with comedonecrosis and ductal-type differentiation

Case 13


61 year old male with left parotid mass slowly growing and recently painful Si787 Oncocytic carcinoma low grade with extensive perineural invasion. P63 positive RCC negative

Case 14


64 year old female with history of palate lesion (junction of hard and soft) four year before presents with a right sided level IIa mass Si787 Metastatic mucoepidermoid carcinoma

Case 15


62 year old female with lesion of the tail of the left parotid Si787 62 year old female with lesion of the tail of the left parotid

Case 16


10 year old female with preauricular cyst Si787 1st branchial cleft cyst work type 2

Case 17


73 years old female with right sinus mass Si787 Moderately differentiated squamous cell carcinoma arising within a largely schnederian papilloma inverted type

Case 18


73 years old female with right sinus mass Si787 Moderately differentiated squamous cell carcinoma arising within a largely schnederian papilloma inverted type

Case 19


67 years old female with right parotid mass Si787 Low-grade salivary gland neoplasm most consistent with adenoid cystic carcinoma KIT negative no PNI --> strange case

Case 20


82 years old male with palate lesion Si787 Myoepithelial predominant pleomorphic adenoma with a diffuse growth pattern (1.6 cm)

Case 21


40 years old male with left parotid mass Si787 Low grade salivary gland neoplasm with atypical features most compatible with cellular myoepithelial predominant pleomorphic adenoma

Case 22


70 years old male with submandibular mass Si787 Infiltrative carcinoma compatible with adenoid cystic carcinoma solid type

Case 23


53 years old female with enlarging mass in right parotid for 8 years Si787 Pleomorphic adenoma. Complete excision.

Case 24


43 years old male with hard palate mass. Rule out malignancy Si787 Myoepithelial rich pleomorphic adenoma

Case 25


62 years old with left parotid mass with extension into the external auditory canal Si787 Mucoepidermoid carcinoma oncocytic type low to focally intermediate grade

Case 26


28 year old male Si787 Myoepithelial–predominant pleomorphic adenoma with atypical features.

Case 27


69 year old male Si787 High-grade poorly differentiated adenocarcinoma most consistent with salivary duct carcinoma.

Case 28


19 year old male Si787 Acinic cell carcinoma with cystic papillary microcystic and solid areas

Case 29


88 year old male Si787 Epithelial-myoepithelial carcinoma

Case 30


50 year old female with mass of left parotid gland. Emw8 Basal cell adenoma

Case 31


70-year-old woman with a 1.7 cm left parotid mass. Pms36 Acinic cell carcinoma (1.7 cm) apparently completely excised with a prominent lymphocytic cuff. Tumor cells are positive for NR4A3 (nuclear) and Dog1 (reticular pattern). The immunohistochemical findings support the diagnosis.

Case 32


70-year-old woman with a 1.7 cm left parotid mass. Pms36 Acinic cell carcinoma (1.7 cm) apparently completely excised with a prominent lymphocytic cuff. Tumor cells are positive for NR4A3 (nuclear) and Dog1 (reticular pattern). The immunohistochemical findings support the diagnosis.