WSI21-136: Cerebrospinal Fluid
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| Case | Clinical history | Requester | Diagnosis |
|---|---|---|---|
| Case | Clinical history | Requester | Diagnosis |
|
| 74-year-old female. History of metastatic breast carcinoma and ventricular shunt placement. | Iac0 | Brain parenchyma. |
|
| 67yo F w/history of metastatic lung adenocarcinoma | Mlz8 | Metastatic adenocarcinoma |
|
| 59 year old man with multiple sclerosis on high dose dexamethasone | Lz17 | Fungal forms consistent with Cryptococcus neoformans. Narrow based budding yeast (do not mistake for RBCs). |
|
| 66 year old M with history of a spine cord lesion and suspicion for Lyme's disease | Lcm51 | Lyme's disease pleocytosis |
|
| 67 year old male with mental status changes and ring enhancing lesions in the parietal lobe. | Cfh13 | No malignant cells identified. Cryptococcus. |
|
| 76 year-old man with a history of CLL and symptoms concerning for new CNS involvement. | Cfh13 | Positive for malignant cells with clonal B cell population on flow cytometry. Clonal B cell population and large malignant cells of unclear etiology. Concurrent surgical specimen: DLBCL consistent with Richter's transformation of patient's known CLL. |
|
| 66 yo F with a history of high grade B cell lymphoma. | Cfh13 | No malignant cells identified. Chondrocytes. |
|
| 25 yo M with a history of medulloblastoma status post resection. | Cfh13 | Poorly differentiated round cell malignancy. IHC on subsequent biopsy confirmed recurrent/residual medulloblastoma. |
|
| 37 yo woman with a history of melanoma | Cfh13 | Metastatic melanoma. |
|
| 65 yo F with NSCLC | Ndk6 | Adenocarcinoma • consistent with metastasis from patient's known lung primary. |
|
| 67 yo M with known metastatic prostate cancer | Ndk6 | Metastatic adenocarcinoma • cytomorphologically consistent with the patient’s known prostate primary |
|
| 59 yo M with a history of AML | Ndk6 | Blasts present • consistent with involvement by the patient's known leukemia. |
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| 48 yo M with a history of adenocarcinoma • lung primary. | Ndk6 | Metastatic adenocarcinoma |
|
| 74yo F with history of lung cancer who presents with acute and chronic intractable nausea and vomiting | Ndk6 | Adenocarcinoma • consistent with metastasis of the patient's known lung primary. |
|
| 66 yo M with a history of transformed follicular lymphoma and CAR-T on trial. | Ndk6 | Positive for malignancy • c/w patient's know transformed follicular lymphoma |
|
| 57 yo M with a history mantle cell lymphoma and known CNS involvement. | Ndk6 | Positive for malignant cells • compatible with involvement by mantle cell lymphoma |
|
| 57 year old male with history of GBM | Ndk6 | Malignant neoplasm • consistent with patient’s known glioblastoma |
|
| 69 YO F with history of B cell lymphoma | Ndk6 | Negative for Malignancy- Abundant acute inflammation • rare lymphocytes and monocytes |
|
| 49 yo F with altered mental status • convulsions • and history of high grade serous carcinoma | Ndk6 | POSITIVE FOR MALIGNANT CELLS- Adenocarcinoma with focally micropapillary and signet ring cell morphology. |
|
| 54 yo F with metastatic breast cancer • leptomeningeal disease suspected | Ndk6 | Carcinoma • consistent with metastasis from patient's known high-grade breast cancer |
|
| 74-year-old man with lytic bone lesions | Lt511 | Plasma cell neoplasm |
|
| 48F with met pancreas cancer with ?LMD | Ndk6 | Metastatic adenocarcinoma |
|
| 76 yo F history of metastatic lung adenocarcinoma • now presenting with new CNS involvement | Ndk6 | Metastatic adenocarcinoma |
|
| 66 yo M | Ndk6 | CSF involvement by the patient’s known multiple myeloma |
