WSI21-134: Pleural, Pericardial, and Peritoneal Fluids

From MGH Learn Pathology


Request type Study
Subspecialty Cytology
Set Cytology
Topic Pleural, Pericardial, and Peritoneal Fluids
Presenter MGH


Toggle columns: Diagnosis

Case Clinical history Requester Diagnosis
Case Clinical history Requester Diagnosis

Case 1


18-year-old male. History of glioblastoma. Iac0 Metastatic glioblastoma.

Case 2


80yo M with left-sided pleural effusion Mlz8 Metastatic small cell lung carcinoma

Case 3


69yo F with pleural effusion Mlz8 Metastatic breast carcinoma (h/o invasive lobular carcinoma)

Case 4


48M kidney failure. Pleura FNA. Iac0 Extramedullary hematopoiesis.

Case 5


Over 90-year old male with significant asbestos exposure Lcm51 Mesothelioma

Case 6


Pericardial effusion and history of parotid mass and atrial mass Mlz8 Metastatic Merkel cell carcinoma (from parotid primary)

Case 7


33F. Peritoneal carcinomatosis. Iac0 SMARCB1/INI1-deficient malignant epithelioid neoplasm.

Case 8


45 y/old F Long Hx of ESRD post kidney transplant. New effusion duodenal mass and peritoneal nodules. Lcm51 PTLD DLBCL type.

Case 9


41M. History of clear cell sarcoma of finger. Iac0 Metastatic clear cell sarcoma.

Case 10


73y/old F with right pleural effusion and flank pain. Aja51 Dx Epithelioid mesothelioma

Case 11


60 y/old F with new pleural effusion and prior "soft tissue" tumor in the arm. Aja51 Metastatic epithelioid hemangioendothelioma

Case 12


79 yo male Ndk6 Multiple myeloma

Case 13


50 yo female with history of metastatic carcinoma with bilateral pleural effusions Ndk6 Metastatic ovarian carcinoma clear cell type

Case 14


65 yo M with a history of myeloma. Cfh13 Positive. Recurrent multiple myeloma to pleura.

Case 15


HISTORY OF MULTIPLE MYEOMA WITH PLASMACYTOMA. NOW HAS PLEURAL EFFUSIONS Pab16 Plasma cell myeloma

Case 16


78 YO male with h/o adenocarcinoma of pyloric antrum and ascites Ndk6 Metastatic adenocarcinoma c/w patient's known malignancy

Case 17


Hx triple negative breast cancer Est105 Metastatic breast carcinoma

Case 18


18-year-old man Eh441 Burkitt lymphoma

Case 19


55 yo F with a remote history of breast carcinoma. Cfh13 Metastatic adenocarcinoma consistent with breast primary.

Case 20


55 yo M with chronic pleural effusion. Cfh13 Positive for malignant cells. Epithelioid hemangioendothelioma.

Case 21


52 yo F with acute respiratory failure in the setting of cocci and remote myeloma. Cfh13 Malignant cells present consistent with involvement by the patient's known multiple myeloma.

Case 22


68yo man with a history of oncocytic thyroid carcinoma (metastatic to one lymph node) and clear cell renal cell carcinoma Ez278 Metastatic oncocytic carcinoma consistent with spread from thyroid primary.

Case 23


68 yo woman with an ovarian mass Cfh13 Positive for metastatic ovarian serous carcinoma in a background of mucinous borderline tumor.

Case 24


73 yo man with ascites noted on surveillance following a Whipple for pancreatic carcinoma Cfh13 Malignant mesothelioma epithelioid type.

Case 25


27 yo F with unrescetable thymic carcinoma Ndk6 Consistent with patient's known thymic carcinoma. Immunohistochemical studies show that the malignant cells are positive for p63 and CD5 supporting the diagnosis.

Case 26


80-year-old man Njc35 Epithelioid mesothelioma.

Fibrosis and multinucleated giant cell reaction to polarizable foreign material consistent with talc pleurodesis.

Note: Immunohistochemistry - tumor cells are positive for calretinin and WT1. They show loss of membranous/ cytoplasmic expression of merlin/NF2. They show retained expression of MTAP.

Case 27


49M ascites fluid Mlz8 Metastatic gastric signet ring cell adenocarcinoma

Case 28


69F. Pleural based mass. Iac0 Epithelioid mesothelioma.

Case 29


73 yo male Dc679 Metastatic Ewing Sarcoma

Case 30


34 yo male with left empyema and c/f lymphoma Ndk6 High-grade B-cell lymphoma consistent with Burkitt lymphoma

Case 31


75 yo male Ndk6 Atypical lymphoid cells present consistent with involvement by mantle cell lymphoma

Case 32


72 yo female with thyroid cancer with recurrent right pleural effusion Ndk6 Metastatic carcinoma consistent with the patient’s thyroid primary

Case 33


67F. Pelvic mass. Pelvic ascites. Iac0 Mucinous epithelium consistent with involvement by ovarian mucinous neoplasm. Resection: borderline mucinous neoplasm.

Case 34


62F. History of papillary thyroid carcinoma. Now with pleural effusion. Iac0 Metastatic papillary thyroid carcinoma.

Case 35


20M. History of CNS lymphoma. Iac0 ALK-positive anaplastic large cell lymphoma (ALCL).