Annotations and notes
- Filename:
Clinical history
61 yo M with HIV and new axillary and mediastinal LAD
Diagnosis
Positive for malignancy- HHV8-positive large cell lymphoma, consistent with primary effusion lymphoma NOTE: The pleural fluid specimen consists of abundant large, atypical lymphoid cells with oval to irregular, convoluted nuclei, dispersed chromatin, and multiple small, prominent nucleoli with a moderate amount of brightly eosinophilic cytoplasm. Immunohistochemistry reveals that the large lymphoid cells stain positively for HHV8 and CD30. CD3 shows weak staining in rare large lymphoid cells and highlights a small population of admixed small, reactive T cells. CD20 and Pax-5 are negative. In-situ hybridization for EBV (EBER) is negative. Overall, the morphologic and immunohistochemical features are consistent with HHV8-related primary effusion lymphoma. An unusual feature is the absence of EBV as most primary effusion lymphomas are co-infected by HHV8 and EBV.
Slides
- No results
[ s or ↓ ] - move viewport down
[ a or ← ] - move viewport left
[ d or → ] - move viewport right
[ 0 ] - zoom 0x (move viewport home)
[ 1 ] - zoom 1x
[ 2 ] - zoom 4x
[ 3 ] - zoom 10x
[ 4 ] - zoom 20x
[ 5 ] - zoom 40x
[ - or _ ] - zoom viewport out
[ + or = ] - zoom viewport in
[ r ] - rotate clockwise
[ R ] - rotate counterclockwise
[ f ] - flip horizontally
[ j ] - change to previous image
[ k ] - change to next image
| Sequence | Case | Clinical history |
|---|---|---|
| 1 | WSI21-134-Case-1 WSI21-134-Case-1 | 18-year-old male. History of glioblastoma. 18-year-old male. History of glioblastoma. |
| 2 | WSI21-134-Case-2 WSI21-134-Case-2 | 80yo M with left-sided pleural effusion 80yo M with left-sided pleural effusion |
| 3 | WSI21-134-Case-3 WSI21-134-Case-3 | 69yo F with pleural effusion 69yo F with pleural effusion |
| 4 | WSI21-134-Case-4 WSI21-134-Case-4 | 48M, kidney failure. Pleura FNA. 48M, kidney failure. Pleura FNA. |
| 5 | WSI21-134-Case-5 WSI21-134-Case-5 | Over 90-year old male with significant asbestos exposure Over 90-year old male with significant asbestos exposure |
| 6 | WSI21-134-Case-6 WSI21-134-Case-6 | Pericardial effusion and history of parotid mass and atrial mass Pericardial effusion and history of parotid mass and atrial mass |
| 7 | WSI21-134-Case-7 WSI21-134-Case-7 | 33F. Peritoneal carcinomatosis. 33F. Peritoneal carcinomatosis. |
| 8 | WSI21-134-Case-8 WSI21-134-Case-8 | 45 y/old F Long Hx of ESRD post kidney transplant. New effusion, duodenal mass and peritoneal nodules. 45 y/old F Long Hx of ESRD post kidney transplant. New effusion, duodenal mass and peritoneal nodules. |
| 9 | WSI21-134-Case-9 WSI21-134-Case-9 | 41M. History of clear cell sarcoma of finger. 41M. History of clear cell sarcoma of finger. |
| 10 | WSI21-134-Case-10 WSI21-134-Case-10 | 73y/old F with right pleural effusion and flank pain. 73y/old F with right pleural effusion and flank pain. |
