WSI21-73-Case-143
From MGH Learn Pathology
High-grade biliary neoplasia.
Note: The specimen shows high-grade glandular epithelium in papillary clusters, cribriforming groups and single cells. Mucinous cytoplasm is present. Background necrosis is not present. There is no subepithelial mucosa showing invasive glands, but an invasive carcinoma cannot be excluded. The findings support a diagnosis of at least high-grade biliary intraepithelial neoplasia. Immunostains submitted for review show retained nuclear staining with SMAD4 and low ki-67 proliferation index.
