WSI21-132: Respiratory Tract and Mediastinum
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| Case | Clinical history | Requester | Diagnosis |
|---|---|---|---|
| Case | Clinical history | Requester | Diagnosis |
|
| 82-year-old female. History of bronchiectasis and MAC. | Iac0 | Abundant neutrophils • granular debris and rare acid-fast bacilli • morphologically compatible with Mycobacterium. |
|
| 29yo M with HIV/AIDS and pulmonary infiltrates | Mlz8 | Pneumocystis pneumonia |
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| 81yo female with multiple lung nodules (slides from right upper lobe nodule) | Mlz8 | Metastatic clear cell carcinoma (endometrial) |
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| 71M. Lung mass. History of sinonasal adenoid cystic carcinoma. | Iac0 | Metastatic adenoid cystic carcinoma. |
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| 61F. Left lower lobe lung mass. | Iac0 | Adenocarcinoma • with papillary features. EGFR mutation. |
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| 50M. BAL. | Iac0 | Histiocytes and proteinaceous debris • consistent with pulmonary alveolar proteinosis. |
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| 76M. History of melanoma. Now with lung mass and hilar lymphadenopathy. | Iac0 | Metastatic poorly differentiated lung adenocarcinoma • with features resembling melanoma. |
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| 68yo man with LLL mass and recent international travel history | Em99 | Histiocytic inflammation and variable sized yeast with narrow-based budding consistent with Cryptococcus microorganisms |
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| 46 F. Left hilar mass. | Iac0 | Granular cell tumor |
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| 82 F. History of anaplastic meningioma. | Iac0 | Metastatic anaplastic meningioma. |
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| 46 F. History of meningioma. | Iac0 | Metastatic meningioma. |
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| 77 y/old M with a right pleural mass | Aja51 | Dx Solitary fibrous tumor |
|
| 84M. History of laryngeal chondrosarcoma. | Iac0 | Recurrent chondrosarcoma. |
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| 82F. History of angiosarcoma. | Iac0 | Metastatic angiosarcoma |
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| 71M. History of cholangiocarcinoma. Pulmonary nodule. | Iac0 | Primary mucinous adenocarcinoma of lung primary. Comparison to prior cholangiocarcinoma show distinctly different cytomorphology. |
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| 79 year old man with bronchiectasis. | Cfh13 | No Malignant Cells Identified. Charcot-Leyden crystals. |
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| 49 year old F with history of carcinoma of the palate and a new lung nodule. | Cfh13 | Adenoid cystic carcinoma. |
|
| 67M. Lung mass. History of lymphoma. | Iac0 | Necrosis and fungal organisms in yeast forms • most consistent with Cryptococcus spp. |
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| 60 yo man with a history of asthma and smoking. New 10 cm hilar mass. | Cfh13 | No malignant cells identified.
Occasional fragments of hyphal forms consistent with Aspergillus sp. Correlation with culture recommended. Charcot Leiden crystals. |
|
| 75 yo F with an omental mass and a history of primary lung malignancy. | Cfh13 | Positive for malignant cells. Consistent with metastatic small cell carcinoma. |
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| 66f. R neck mass arising from thyroid cartilage. | Iac0 | Low-grade chondrosarcoma. |
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| 73yo M with left upper lobe lung nodule | Mlz8 | Metastatic renal cell carcinoma • clear cell type |
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| 43yo M w/right upper lobe lung nodule | Mlz8 | Metastatic urachal adenocarcinoma • enteric type |
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| 82M • history of prostate cancer | Mlz8 | Metastatic prostatic adenocarcinoma |
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| 70M with left perihilar lung mass | Mlz8 | Pulmonary hamartoma |
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| 54F. History of breast carcinoma. 10R lymph node biopsy. | Iac0 | Metastatic triple-negative breast carcinoma. |
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| hx 3 cm LLL nodule | Est105 | Well-differentiated neuroendocrine tumor/carcinoid • NOS |
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| 75F lung nodular opacity. | Iac0 | Fungal organisms • consistent with Aspergillus spp. |
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| 53 yo male with CLL | Ndk6 | Cryptococcus |
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| 47F. Hx of pleomorphic adenoma of parotid gland. Now with lung mass. | Iac0 | Benign metastasizing pleomorphic adenoma |
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| 66 yo male s/p lung transplant | Ndk6 | Fungal organisms morphologically consistent with Aspergillus species |
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| 85M. Hx of CLL. Multiple bilateral cavitary and non-cavitary lung nodules. | Iac0 | Granulomatous inflammation with fungal organisms in yeast form • consistent with Cryptococcus. |
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| 87M • RLL lung nodule | Mlz8 | Metastatic urothelial carcinoma |
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| 73 YO male with pulmonary infiltrates and mediastinal lymphadenopathy | Ndk6 | Positive for adenocarcinoma and fungal organisms morphologically consistent with Aspergillus species. |
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| 18 YO female | Ndk6 | Negative for malignancy- Cellular changes characteristic of Herpes simplex virus |
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| 75 YO male with hemoptysis | Ndk6 | Adenocarcinoma |
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| 65 YO male with newly enlarging right lung mass | Ndk6 | Adenocarcinoma with papillary features |
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| 75 yo M with a cavitary lung mass. | Cfh13 | No malignant cells identified. Abundant fungal organisms in a background of necrotic debris. The fungi shows non-septate branching hyphae with scattered fungal spores with budding • morphologically consistent with Zygomycetes. |
|
| 56 yo M who presented after having dinner in a steakhouse. | Cfh13 | No malignant cells identified. Pulmonary macrophages and acute inflammation. Fragment of skeletal muscle consistent with aspiration. |
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| 71 year old female with mediastinal mass | Aja51 | Thymoma • Type A |
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| 79 yo M never smoker with a 2 cm well-defined pulmonary nodule | Cfh13 | Amyloidoma. |
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| 86-year-old woman with hypoxemic respiratory failure | Lt511 | Herpes infection |
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| 73 year old male | Dc679 | No cardia |
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| 90 yo male | Dc679 | Metastatic Melanoma |
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| 49F. History of adenoid cystic carcinoma. Now with pleural mass. | Iac0 | Metastatic adenoid cystic carcinoma. |
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| 57 yo m w/ chest wall mass | Ndk6 | Small cell carcinoma |
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| 67M. Pleural mass. | Iac0 | Epithelioid mesothelioma. |
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| 60 yo m w/ RML lung nodule and h/o salivary gland ca | Ndk6 | Metastatic adenoid cystic carcinoma |
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| 63 yo m w/ pseudomembranous formation and cobble stoning throughout airways • concern for infection fungal vs viral | Ndk6 | Fungal organisms morphologically consistent with Aspergillus species |
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| 71M. Hx of adenoid cystic carcinoma of submandibular gland. | Iac0 | Metastatic adenoid cystic carcinoma. |
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| 63M. History of colorectal adenocarcinoma. | Iac0 | Metastatic colorectal adenocarcinoma. |
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| 67 yo female with left lower lobe lung nodule biopsy and history of lymphoma | Ndk6 | B-cell lymphoma • consistent with the patient’s known Mantle cell lymphoma. |
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| 43-year-old man with LUL nodule | Lt511 | Pulmonary adenofibroma |
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| 74-year-old woman with pulmonary nodule | Lt511 | Metastatic adenoid cystic carcinoma |
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| 53-year-old man with history of lung transplant | Lt511 | True lipid droplets on Oil Red O in a background of hemosiderin-laden macrophages |
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| 55yo F s/p lung transplant | Ndk6 | Bronchial columnar cells • pulmonary macrophages • and abundant fungal hyphae c/w Aspergillus |
|
| 58 yo femlae • Chordoma of sacrum • multiple pulmonary nodules | Ndk6 | Epithelioid neoplasm with abundant bubbly cytoplasm and associated myxoid stroma • cytomorphologically compatible with metastatic chordoma |
|
| history of shoulder melanoma • new lung lesion | Mu451 | metastatic melanoma |
