DZI20-205: MML NP

From MGH Learn Pathology


Request type Study
Subspecialty Neuropathology
Set Frozen Conference
Topic MML NP
Presenter Martinez-Lage Alvarez, Maria,MD


Toggle columns: Diagnosis

Case Clinical history Requester Diagnosis
Case Clinical history Requester Diagnosis

Case 1


27-year-old man presenting with posterior fossa brain mass. Mjf79 Frozen: Medulloblastoma. permanent: MEDULLOBLASTOMA CLASSICAL TYPE WNT-ACTIVATED WHO GRADE IV

Case 2


46 yo R posterior parietal rim-enhancing lesion. Mjf79 Frozen: Glial tumor suspect high-grade. Rapid IDH and MGMT ordered. permanent: INTEGRATED DIAGNOSIS: GLIOBLASTOMA IDH-WILDTYPE

Case 3


55 yo M with incidental pituitary mass Mjf79 Frozen: Consistent with Rathke's cleft cyst with strips of epithelium. permament: RATHKE'S CLEFT CYST

Case 4


80 yo M hypodense lesion with significant edema in R temporal lobe Mjf79 "Frozen: Infiltrating glioma. DH plus MGMT testing initiated."permament: INTEGRATED DIAGNOSIS: DIFFUSE ASTROCYTOMA IDH-MUTANT.

Case 5


77 yo with sinus opacification and enhancing cystic lesion in sella Mjf79 Frozen: Largely acellular material with refractile material resembling fungal forms versus crystals. No definitive viable fungi seen. Permanent: ACELLULAR MATERIAL WITH FUNGAL HYPHAE

Case 6


68 yo M with MRI demonstrating R temporal expansile T2/FLAIR signal hyperintense lesion with at most punctate enhancement. Mjf79 "Frozen#1(slides 1-3): Brain with infiltrating atypical cells.

Frozen#2(slides 4-6): High-grade astrocytoma at least grade 3. Rapid MGMT requested."

Permanent: GBM IDH-WT

Case 7


64 yo with CT showing a right temporal lobe mass. Mjf79 Frozen: Malignant neoplasm favor melanoma. Rapid molecular initiated. Permanent: METASTATIC MELANOMA

Case 8


64 yo M with expansile enhancing intramedullary mass extending from C4 to T7. Mjf79 Frozen: Hypercellular glial tissue suggestive of glioma. Permanent: INFILTRATING ASTROCYTOMA

Case 9


54 yo F with CT head that showed corpus callosum mass and associated edema in posterior parietal lobes Mjf79 Frozen: Lesional tissue suspicious for lymphoma. Permanent: DIFFUSE LARGE B CELL LYMPHOMA (DLBCL) NON-GERMINAL CENTER TYPE

Case 10


77 yo with CT showing extra-axial mass measuring 6.6x2.5cm with significant vasogenic edema in the right frontal lobe with effacement of the frontal horn of the right lateral ventricle and 0.4cm midline shift to the L Mjf79 Frozen: Atypical meningioma (sheeting foci of hypercellularity necrosis mitosis). Permanent: ATYPICAL MENINGIOMA WHO GRADE II

Case 11


51-year-old male with a cystic sellar mass Mjf79 Frozen: Consistent with craniopharyngioma. Permanent: PAPILLARY CRANIOPHARYNGIOMA