DZI19-42-Case-1
60 year old man with a 3 cm right sided neck mass. An FNA showed benign salivary gland tissue.
Acinic cell carcinoma
- Malignant salivary gland neoplasm with serous acinar differentiation
- Parotid gland most common location
- Generally good prognosis
- Histological patterns: solid/lobular, papillary-cystic, microcystic
- PAS+ diastase-resistant zymogen granules
- DOG1 positive
June 24, 2019
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Clinical history
60 year old man with a 3 cm right sided neck mass. An FNA showed benign salivary gland tissue.
Diagnosis
Acinic cell carcinoma Malignant salivary gland neoplasm with serous acinar differentiation Parotid gland most common location Generally good prognosis Histological patterns: solid/lobular, papillary-cystic, microcystic PAS+ diastase-resistant zymogen granules DOG1 positive
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Associated requests
DZI19-42
Sequence | Case | Clinical history | Diagnosis |
---|---|---|---|
1 | DZI19-42-Case-1 | 60 year old man with a 3 cm right sided neck mass. An FNA showed benign salivary gland tissue. 60 year old man with a 3 cm right sided neck mass. An FNA showed benign salivary gland tissue. | Acinic cell carcinoma
* Malignant salivary gland neoplasm with serous acinar differentiation
* Parotid gland most common location
* Generally good prognosis
* Histological patterns: solid/lobular, papillary-cystic, microcystic
* PAS+ diastase-resistant zymogen granules
* DOG1 positive Acinic cell carcinoma
* Malignant salivary gland neoplasm with serous acinar differentiation
* Parotid gland most common location
* Generally good prognosis
* Histological patterns: solid/lobular, papillary-cystic, microcystic
* PAS+ diastase-resistant zymogen granules
* DOG1 positive |
2 | DZI19-42-Case-2 | 50 year old man with right sided facial paralysis and a mass in the right parapharyngeal space 50 year old man with right sided facial paralysis and a mass in the right parapharyngeal space | Mucoepidermoid carcinoma, high grade
* Malignant salivary gland tumor with variable components of mucous, epidermoid, and intermediate cells
* Most common malignant salivary gland tumor in adults and children
* Grading important for prognosis but challenging
* Characteristic molecular finding: t(11;19) CRTC1-MAML2 (less common t(11;15) CRTC3-MAML2) Mucoepidermoid carcinoma, high grade
* Malignant salivary gland tumor with variable components of mucous, epidermoid, and intermediate cells
* Most common malignant salivary gland tumor in adults and children
* Grading important for prognosis but challenging
* Characteristic molecular finding: t(11;19) CRTC1-MAML2 (less common t(11;15) CRTC3-MAML2) |
3 | DZI19-42-Case-3 | 64 year old man with blurry vision, diplopia, and a mass involving the right ethmoid sinus 64 year old man with blurry vision, diplopia, and a mass involving the right ethmoid sinus | Adenoid cystic carcinoma
* Malignant salivary gland tumor with myoepithelial and ductal differentiation.
* Primarily affects adults
* Histological patterns: tubular, cribriform, solid
* Hyalinized/myxoid/mucoid filled spaces
* Perineural invasion is almost universal (pain, facial palsy...)
* Characteristic molecular: t(6;9) MYB-NFIB
* MYB IHC can be useful but is not 100% specific Adenoid cystic carcinoma
* Malignant salivary gland tumor with myoepithelial and ductal differentiation.
* Primarily affects adults
* Histological patterns: tubular, cribriform, solid
* Hyalinized/myxoid/mucoid filled spaces
* Perineural invasion is almost universal (pain, facial palsy...)
* Characteristic molecular: t(6;9) MYB-NFIB
* MYB IHC can be useful but is not 100% specific |
4 | DZI19-42-Case-4 | 55 year old man with a one year of nasal congestion, epistaxis and drainage, and a large mass in the right nasal cavity 55 year old man with a one year of nasal congestion, epistaxis and drainage, and a large mass in the right nasal cavity | HPV-related multiphenotypic sinonasal carcinoma, previously called HPV-related adenoic cystic-like carcinoma HPV-related multiphenotypic sinonasal carcinoma, previously called HPV-related adenoic cystic-like carcinoma |
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