WSI24-474: PPS mystery cases
From MGH Learn Pathology
Request details
- Request type Cme
- Subspecialty Pulmonary Pathology
- Set PP teaching set
- Topic PPS mystery cases
- Presenter Mino-Kenudson, Mari,MD
- Date and time Friday, June 26, 2026 12:00 PM
| Case | Clinical history | Requester |
|---|---|---|
| Case | Clinical history | Requester |
|
| A 70-year-old man with a remote smoking history and no prior cancer history presented with severe right upper lobe (RUL) pneumonia. Diagnostic investigations were initiated after persistence of RUL atelectasis following a course of antibiotics • leading to the finding of a 2.1 cm RUL endobronchial mass with an SUV of 2.8. An endobronchial biopsy of the mass was performed. | Mm768 |
|
| A 48-year-old man presented with a round lesion in the lower lobe of the left lung. His medical history was notable for p16-positive squamous cell carcinoma of the tonsil with molecular pathologic evidence of a high-risk HPV type • which had been treated with radiation therapy one year earlier. Two years previously • he had also been diagnosed with squamous cell papillomas of the soft palate • uvula • and tonsil • with evidence of HPV type 11 infection. Wedge resection of segment 8 of the left lung was performed. | Mm768 |
|
| A 67-year-old man with a past medical history significant for dyslipidemia and hypothyroidism presented with progressive dyspnea of two months’ duration. A chest radiograph demonstrated a left-sided pleural effusion. Subsequent magnetic resonance imaging (MRI) of the thorax revealed • in addition to the pleural effusion • a mass in the anterior mediastinum associated with pleural nodules. A biopsy of a pleural nodule was performed. | Mm768 |
|
| A 70-year-old never-smoker with familial pulmonary fibrosis • premature graying since his 30s • and opioid use disorder underwent bilateral lung transplant for progressive fibrosing ILD initially classified as IPAF. Occupational history was notable for more than two decades of indoor traffic-signal assembly without respiratory protection. | Mm768 |
|
| A 65-year-old woman with a past medical history of diabetes mellitus • hyperlipidemia and recent cardiovascular accident with left sided weakness and an incidentally discovered right lower lobe lung mass; biopsy showed an atypical spindle cell neoplasm and tumor was excised. | Mm768 |
|
| A 74-year-old man • former smoker • presented for biopsy of a 1.2 cm right lower lobe spiculated nodule. A biopsy of the nodule was performed. | Mm768 |
