WSI24-294-Case-2
32 yo woman with 2 weeks of headaches and mild nausea when changing head position
Integrated diagnosis: ASTROCYTOMA, IDH-MUTANT, CNS WHO GRADE 3 Histological diagnosis: gemistocytic astrocytoma with mitotic activity CNS WHO grade: 3 Molecular information: IDH: mutant (R132H, IDH1/2 PCR sequencing) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation) CDKN2A/B: maintained (FISH) MGMT promoter: methylated (methylation specific PCR)
May 2, 2025 12:00:00 PM
