WSI24-104-Case-271

48 year old woman with 3 cm nasal mass which extends to the posterior choana and nasopharyx.

Biphenotypic sinonasal sarcoma.

S100 protein: positive, diffuse SMA: positive, patchy Desmin: positive, focal CD34: negative STAT6: negative Sox 10 negative AE1/3: negative Nuclear b-catenin: positive, focal Pan-TRK: positive, focal

FISH shows pAX3 gene translocation

May 9, 2024 1:53:00 PM

WSI24-104

/ Case 271

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Clinical history

48 year old woman with 3 cm nasal mass which extends to the posterior choana and nasopharyx.

Diagnosis

Biphenotypic sinonasal sarcoma. S100 protein: positive, diffuse SMA: positive, patchy Desmin: positive, focal CD34: negative STAT6: negative Sox 10 negative AE1/3: negative Nuclear b-catenin: positive, focal Pan-TRK: positive, focal FISH shows pAX3 gene translocation

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