DZI19-101-Case-6

Sequence	Case	Clinical history	Diagnosis
1	DZI19-101-Case-1 DZI19-101-Case-1	Breast biopsy for architectural distortion. Please compare and contrast the circled epithelial proliferations (cell size, polarity, monotony). How would each stain for Keratin 5/6 and ER? Breast biopsy for architectural distortion. Please compare and contrast the circled epithelial proliferations (cell size, polarity, monotony). How would each stain for Keratin 5/6 and ER?	- Focal atypical ductal hyperplasia and flat epithelial atypia. - Sclerosing lesion with usual ductal hyperplasia. - Focal atypical ductal hyperplasia and flat epithelial atypia. - Sclerosing lesion with usual ductal hyperplasia.
2	DZI19-101-Case-2 DZI19-101-Case-2	Breast tissue adjacent to a low-grade IDC. Classify the circled proliferation and describe the spectrum of cytologic features. (bonus: what is going on with that mucin near the single black line?) Breast tissue adjacent to a low-grade IDC. Classify the circled proliferation and describe the spectrum of cytologic features. (bonus: what is going on with that mucin near the single black line?)	Atypical ductal hyperplasia, flat epithelial atypia, and lobular neoplasia showing identical nuclear features and divergent architecture/cohesion. Atypical ductal hyperplasia, flat epithelial atypia, and lobular neoplasia showing identical nuclear features and divergent architecture/cohesion.
3	DZI19-101-Case-3 DZI19-101-Case-3	Identify the anatomic structure and classify/describe the epithelial proliferation. Identify the anatomic structure and classify/describe the epithelial proliferation.	High-grade ductal carcinoma in-situ involving lactiferous ducts with extension into the nipple epidermis (Paget's disease of the nipple). High-grade ductal carcinoma in-situ involving lactiferous ducts with extension into the nipple epidermis (Paget's disease of the nipple).
4	DZI19-101-Case-4 DZI19-101-Case-4	Identify the anatomic structure and underlying process. Describe the cellular proliferation. Final diagnosis? Identify the anatomic structure and underlying process. Describe the cellular proliferation. Final diagnosis?	Focal microinvasive ductal carcinoma arising from low-grade ductal carcinoma in-situ involving a nipple adenoma. Focal microinvasive ductal carcinoma arising from low-grade ductal carcinoma in-situ involving a nipple adenoma.
5	DZI19-101-Case-5 DZI19-101-Case-5	Section from a 10 cm palpable breast mass. Super busy slide -- what histologic features differentiate true invasive carcinoma from mimics such as biopsy tract displacement and radial scars? Section from a 10 cm palpable breast mass. Super busy slide -- what histologic features differentiate true invasive carcinoma from mimics such as biopsy tract displacement and radial scars?	- Invasive ductal carcinoma arising from ductal carcinoma in-situ involving a complex sclerosing lesion. - Biopsy site. - Invasive ductal carcinoma arising from ductal carcinoma in-situ involving a complex sclerosing lesion. - Biopsy site.
6	DZI19-101-Case-6 DZI19-101-Case-6	35-y/o with 4cm breast mass. Describe the tissue. Is it concordant? 35-y/o with 4cm breast mass. Describe the tissue. Is it concordant?	- Diabetic mastopathy. - Diabetic mastopathy.
7	DZI19-101-Case-7 DZI19-101-Case-7	70-y/o-female with a small mass. 70-y/o-female with a small mass.	Benign duct adenoma (?myoepithelioma?) Benign duct adenoma (?myoepithelioma?)
8	DZI19-101-Case-8 DZI19-101-Case-8	50-y/o-female with new left breast calcifications. History of grade 1 DCIS. 50-y/o-female with new left breast calcifications. History of grade 1 DCIS.	- Calcifications associated with benign lobules with radiation effect. - Lobular neoplasia with radiation effect. - Scar consistent with prior lumpectomy site. - Calcifications associated with benign lobules with radiation effect. - Lobular neoplasia with radiation effect. - Scar consistent with prior lumpectomy site.
9	DZI19-101-Case-9 DZI19-101-Case-9	Describe the proliferation. Final diagnosis? Describe the proliferation. Final diagnosis?	- Invasive secretory carcinoma - Invasive secretory carcinoma

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