WSI21-131: Cervical and Vaginal Cytology
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| Case | Clinical history | Requester | Diagnosis |
|---|---|---|---|
| Case | Clinical history | Requester | Diagnosis |
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| 29-year-old female. Presenting to clinic for removal of copper IUD. | Iac0 | NILM Reactive changes consistent with IUD effect. |
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| 71yo F with postmenopausal bleeding | Mlz8 | Endometrial adenocarcinoma (SP: high grade serous carcinoma of endometrium) |
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| 59yo female with multiple myeloma s/p chemotherapy and BMT • annual pap smear | Mlz8 | Atypical squamous cells • favor reactive changes due to chemotherapy (SP: Benign) |
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| 32yo F screening pap | Mlz8 | HSIL (HPV 16+) |
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| 73yo F with postmenopausal bleeding | Mlz8 | AGUS • favor neoplastic (Concurrent endometrial biopsy: endometrial endometrioid adenocarcinoma • Grade 1) |
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| 73yo female with postmenopausal bleeding | Mlz8 | Endometrial adenocarcinoma (concurrent EMB: endometrioid adenocarcinoma • grade 2 • arising in a polyp) |
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| 36yo female • h/o HSIL • HPV16+ | Mlz8 | HSIL with high-grade keratinizing dysplasia • suggestive for squamous cell carcinoma |
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| 71yo female with history of metastatic colon cancer | Mlz8 | Adenocarcinoma • consistent with colon primary (concurrent biopsy showed same with ancillary studies) |
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| 73F. Post menopausal bleeding | Iac0 | Adenocarcinoma. Resection - carcinosarcoma. |
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| 62y/old F with post menstrual bleeding and a lobulated fundic mass. | Aja51 | Dx Endocervical adenocarcinoma |
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| 45 year-old female with an IUD. Negative for HPV | Cfh13 | Negative for intraepithelial lesion or malignancy. Reactive changes related to IUD. |
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| 21 year-old female with an IUD and no significant GYN history | Cfh13 | Negative for intraepithelial lesion or malignancy. Reactive IUD changes. Actinomyces |
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| 50 year-old • postmenopausal female with a cervical mass and a history of multiple myeloma. | Cfh13 | Abundant plasma cells consistent with involvement by the patient's known myeloma. |
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| 44F. | Iac0 | HSIL. Nucleoli and keratinization raise the possibility of invasion • but diathesis is lacking. |
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| 66 yo female with postmenopausal bleeding | Ndk6 | Endometrial Adenocarcinoma |
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| 40 year old woman. Routine screening pap. HPV +18. | Cfh13 | Endocervical adenocarcinoma in situ. Confirmed on subsequent LEEP. |
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| 79F. History of cervical cancer post chemoradiation. | Iac0 | Reactive changes • consistent with radiation effect. |
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| 25 yo woman. First screening pap. | Cfh13 | LSIL. |
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| 55yo post-menopausal with history of plasma cell myeloma. New • expanding cervical/adnexal mass. Pelvic exam reveals a cervix replaced by a large mass • mostly submucosal • with some central cervical invasion. Ultrasound reveals a left parametria extension of mass • measuring 6 cm. | Lr295 | Plasmacytoma • poorly differentiated (stains CD138 + with monoclonal kappa light chain population). |
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| 32 yo F at screening visit with no prior abnormal pap smears. | Cfh13 | Negative for intraepithelial lesion or malignancy. Reactive changes. Cellular changes consistent with herpes simplex virus |
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| 57 yo F status post TAH for endometrioid adenocarcinoma. Concurrent biopsy taken. | Cfh13 | Epithelial cell abnormality - Glandular. Endometrial adenocarcinoma. |
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| 44 year old - Pap 2021 ASCUS/+HPV 16 with negative colpo • now +HPV16 | Est105 | AIS |
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| 26 yo F with an IUD and a history of LSIL and high-risk HPV. | Cfh13 | Negative for intraepithelial lesion or malignancy. Pseudoactinomycotic radiate granule (PAMRAG). |
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| 52 yo F with all prior pap negative and HPV negative. | Tz046 | Negative pap. Transitional cell metaplasia in a background of atrophic changes. |
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| 60 year old woman with postmenopausal bleeding | Mk213 | Epithelial cell abnormality - glandular
Atypical endometrial cells • favor neoplastic. Concurrent surgical endometrial biopsy: Endometroid adenocarcinoma • grade 2 of 3. |
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| hx LSIL | Est105 | LSIL but also HSV |
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| 34 yo F. All prior paps negative. HPV 16 and 45 positive. | Cfh13 | ASCUS. Trichomonas vaginalis present. Asperity. |
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| 67 yo F presenting for routine pap screening. | Cfh13 | ASCUS. Cellular changes consistent with herpes simplex virus. Atrophic changes present. Acute inflammation. |
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| 36 yo F with IUD on routine screening | Cfh13 | Epithelial cell abnormality - glandular. Atypical endocervical cells • NOS. |
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| 32 yo F with a prior AGUS pap | Cfh13 | Endocervical adenocarcinoma in situ. Candida. |
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| 28 yo F with intermenstrual bleeding | Cfh13 | High grade squamous intraepithelial lesion |
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| 30 YO • routine pap | Td693 | Endocervical Adenocarcinoma is situ |
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| 69F. Pap smear. | Iac0 | Endometrial endometrioid adenocarcinoma. |
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| 60F. Post menopausal. | Iac0 | Adenocarcinoma. |
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| 55F. History of colorectal adenocarcinoma. | Iac0 | Extrauterine adenocarcinoma. |
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| 49F | Mlz8 | NILM reactive • concurrent biopsy lower uterine segment polyp |
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| 29 yo F | Ndk6 | Herpes simplex virus |
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| 34F | Mlz8 | HSV |
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| 68F | Mlz8 | Endometrial adenocarcinoma |
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| 35 year old woman with history of squamous intraepithelial lesion | Njc35 | High grade squamous intraepithelial lesion. Fungal organisms morphologically consistent with Candida species. |
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| 24F • pregnant | Mlz8 | Asperities (ASCUS) |
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| 52 YO | Ndk6 | Squamous Cell Carcinoma |
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| 26 YO history of ASCUS • HPV neg | Ndk6 | Low grade squamous intraepithelial lesion |
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| 39 YO with history of dysplasia | Ndk6 | Low grade squamous intraepithelial lesion. |
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| 53 YO postmenopausal | Ndk6 | NILM with tubal metaplasia |
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| 53 yo F with history of TAH | Ndk6 | Low grade squamous intraepithelial lesion |
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| 47 yo F | Ndk6 | NILM- fungal organisms consistent with Candida species present |
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| 31 yo F. Screening pap smear. | Cfh13 | Cytology: HSIL. Biopsy: Moderate squamous dysplasia. |
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| post Menopausal. ASH-H | Sxm | High-grade squamous dysplasia • probably with endocervical glandular involvement. |
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| AIN2 s/p HYF 12/2022 | Sxm | Epithelial Cell Abnormality - Squamous: High grade squamous intraepithelial lesion. |
|
| 72 yo female | Dc679 | A. CERVICAL • LIQUID BASED SPECIMEN:
SPECIMEN ADEQUACY: Satisfactory for evaluation. INTERPRETATION: EPITHELIAL CELL ABNORMALITY - GLANDULAR. Endometrial adenocarcinoma. ADDITIONAL INFORMATION: This specimen was prescreened using the BD FocalPoint GS Imaging System. |
|
| 48 yo female | Dc679 | A. CERVICAL • LIQUID BASED SPECIMEN:
SPECIMEN ADEQUACY: Satisfactory for evaluation. INTERPRETATION: EPITHELIAL CELL ABNORMALITY - SQUAMOUS. High grade squamous intraepithelial lesion with features concerning for invasion. ADDITIONAL INFORMATION: This specimen was prescreened using the BD FocalPoint GS Imaging System. |
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| 32 yo F | Ndk6 | ASCUS and trichomonas vaginalis • actinomyces species • and candida species. |
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| 22 yo f | Ndk6 | LSIL |
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| 42F | Mlz8 | ASCUS (asperites) |
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| 42F | Mlz8 | ASCUS atypical repair |
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| 62 yo woman with cervical friability | Lt511 | High grade squamous intraepithelial lesion. Invasive squamous cell carcinoma cannot be excluded |
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| 45F. History of LSIL. Mirena IUD. | Iac0 | LSIL. IUD effect. HPV-negative. |
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| 70 yo f w/ recurrent ovarian cancer with friable vaginal mass | Ndk6 | EPITHELIAL CELL ABNORMALITY - GLANDULAR. Malignant neoplasm with features consistent with patient’s known malignant mixed mesodermal tumor. |
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| 62 yo f w/ vulvar mass | Ndk6 | Squamous cell carcinoma |
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| 67 yo F | Ndk6 | High grade squamous intraepithelial lesion |
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| 74 yo f w/ postmenopausal bleeding • endometrial stripe thickening • and a 2.8 cm endocervical mass | Ndk6 | Adenocarcinoma Bx: Endometrial serous carcinoma |
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| 48 yo f w/ IUD | Ndk6 | NILM- endometrial cells >45 • trichomonas vaginalis • actinomyces • and reactive cellular changes consistent with IUD effect |
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| 21-year-old woman with recent pelvic pain presents for first pap smear | Ez278 | Negative for intraepithelial lesion or malignancy. Cellular changes consistent with herpes simplex virus. |
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| 34-year-old M with history of AIN 2-3 and HSIL anal pap s/p HYF. High-risk HPV positive. | Ez278 | High grade squamous intraepithelial lesion (HSIL) |
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| 40F • cervical pap | Mlz8 | NILM • Trichomonas |
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| 75 years old woman with postmenopausal bleeding | Lt511 | Endometrial adenocarcinoma |
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| 35-year-old woman • HPV negative | Lt511 | HSIL |
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| Trichomonas | Sxm | Trichomonas |
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| Herpes | Sxm | Herpes |
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| 40 yo F. Screening pap. | Ndk6 | NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY- Trichomonas vaginalis |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 36 yo F positive for HPV 16 | Ndk6 | High grade squamous intraepithelial lesion. |
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| 21 yo F w/ IUD | Ndk6 | Low grade squamous intraepithelial lesion and Trichomonas vaginalis |
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| 74 yo F w/ PMB | Ndk6 | Endometrial adenocarcinoma |
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| 62 yo F | Ndk6 | NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY- Follicular cervicitis |
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| 74 yo F presenting with post menopausal bleeding and friable cervix | Ndk6 | Endometrial adenocarcinoma |
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| 36 yo HPV 16+ | Ndk6 | High grade squamous intraepithelial lesion |
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| 41 yo Cervical high risk HPV +16 | Ndk6 | Endocervical adenocarcinoma • at least in-situ. |
