Difference between revisions of "DZI19-121-Case-3"

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Histological diagnosis: Anaplastic astrocytoma (recurrent)
 
Histological diagnosis: Anaplastic astrocytoma (recurrent)
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ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
 
CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
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Revision as of 13:39, March 9, 2022

DZI19-121-Case-3
45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT

Histological diagnosis: Anaplastic astrocytoma (recurrent)

WHO histological grade: III

Molecular information: IDH: MUTANT (R132H immunohistochemistry) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)

CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
December 31, 1969 7:00:00 PM






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