Difference between revisions of "WSI21-76"

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Revision as of 12:08, March 9, 2022


Request type Outs
Subspecialty Hematopathology
Topic 2021/04/19
Presenter Hasserjian, Robert P.,MD
Date and time Monday, April 19, 2021 12:00 AM



Case Clinical history Requester
Case Clinical history Requester

Case 1


65 year-old woman with history of essential thrombocythemia for 4 years. Now marked increase in platelets. WBC 21.4 x 109/L (80% polys 11% lymphs 5% monos 1% eos 1% basos) HGB 17.5 g/dL PLT 1 415 x 109/L. Rh27

Case 2


16 year-old female with history of ITP now normal platelets but mild leukocytosis and rare circulating blasts. WBC 11.3 x 109/L (71% polys 17% lymphs 8% monos 2% eos 2% basos) HGB 11.2 g/dL PLT 199 x 109/L. Rh27

Case 3


82 year-old female with history of chronic renal failure due to autoimmune disease; previous anemia of chronic disease on EPO therapy now has become leukopenic and thrombocytopenic. WBC 0.6 x 109/L (23% polys 66% lymphs 11% eos) HGB 6.7 g/dL PLT 13 x 109/L. Rh27

Case 4


47 year-old male. No history or CBC provided. Rh27

Case 5


61 year-old male with lymphadenopathy hepatosplenomegaly and pancytopenia. Rh27

Case 6


60 year-old male with leukocytosis concern for CML. WBC 138.07 x 109/L (44% polys 11% bands 2% lymphs 12% monos 8% eos 1% basos 8% myelocytes 8% metamyelocytes 6% promyelocytes 1% blasts) HGB 7.8 g/dL PLT 98 x 109/L. Rh27

Case 7


67 year-old man with history of colon cancer post right hemicolectomy and chemotherapy now found to have leukocytosis. WBC 30.4 x 109/L HGB 8.6 g/dL PLT 284 x 109/L. Karyotype normal. NGS shows ASXL1 p.Gln910Argfs*14 truncating mutation (VAF 10%). Rh27