Difference between revisions of "DZI19-121-Case-5"

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Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-5
38 y.o. woman with a 2 month hx of positional vertigo, L facial weakness, tinnitus, and left anterior tongue numbness
Integrated diagnosis:

DIFFUSE MIDLINE GLIOMA, H3K27M-MUTANT

Histological diagnosis: Anaplastic astrocytoma

WHO (integrated histological and molecular) grade: IV

Molecular information: H3K27M: MUTANT (immunohistochemistry) IDH: wildtype (IDH1/2 PCR sequencing) P53: negative in tumor cells (immunohistochemistry, consistent with wildtype) ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype)

MGMT promoter: unmethylated (methylation specific PCR)
December 31, 1969 7:00:00 PM