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S100 protein: positive, diffuse SMA: positive, patchy Desmin: positive, focal CD34: negative STAT6: negative Sox 10 negative AE1/3: negative Nuclear b-catenin: positive, focal Pan-TRK: positive, focal
FISH shows pAX3 gene translocation
Annotations and notes
Clinical history
48 year old woman with 3 cm nasal mass which extends to the posterior choana and nasopharyx.
Diagnosis
Biphenotypic sinonasal sarcoma. S100 protein: positive, diffuse SMA: positive, patchy Desmin: positive, focal CD34: negative STAT6: negative Sox 10 negative AE1/3: negative Nuclear b-catenin: positive, focal Pan-TRK: positive, focal FISH shows pAX3 gene translocation
Slides
