WSI21-131

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Subspecialty Cytology

Set Cytology

Topic Cervical and Vaginal Cytology

Presenter MGH

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Toggle columns: Diagnosis

Case	Clinical history	Requester	Diagnosis
Case	Clinical history	Requester	Diagnosis
Case 1	29-year-old female. Presenting to clinic for removal of copper IUD.	Iac0	NILM Reactive changes consistent with IUD effect.
Case 2	71yo F with postmenopausal bleeding	Mlz8	Endometrial adenocarcinoma (SP: high grade serous carcinoma of endometrium)
Case 3	59yo female with multiple myeloma s/p chemotherapy and BMT • annual pap smear	Mlz8	Atypical squamous cells • favor reactive changes due to chemotherapy (SP: Benign)
Case 4	32yo F screening pap	Mlz8	HSIL (HPV 16+)
Case 5	73yo F with postmenopausal bleeding	Mlz8	AGUS • favor neoplastic (Concurrent endometrial biopsy: endometrial endometrioid adenocarcinoma • Grade 1)
Case 6	73yo female with postmenopausal bleeding	Mlz8	Endometrial adenocarcinoma (concurrent EMB: endometrioid adenocarcinoma • grade 2 • arising in a polyp)
Case 7	36yo female • h/o HSIL • HPV16+	Mlz8	HSIL with high-grade keratinizing dysplasia • suggestive for squamous cell carcinoma
Case 8	71yo female with history of metastatic colon cancer	Mlz8	Adenocarcinoma • consistent with colon primary (concurrent biopsy showed same with ancillary studies)
Case 9	73F. Post menopausal bleeding	Iac0	Adenocarcinoma. Resection - carcinosarcoma.
Case 10	62y/old F with post menstrual bleeding and a lobulated fundic mass.	Aja51	Dx Endocervical adenocarcinoma
Case 11	45 year-old female with an IUD. Negative for HPV	Cfh13	Negative for intraepithelial lesion or malignancy. Reactive changes related to IUD.
Case 12	21 year-old female with an IUD and no significant GYN history	Cfh13	Negative for intraepithelial lesion or malignancy. Reactive IUD changes. Actinomyces
Case 13	50 year-old • postmenopausal female with a cervical mass and a history of multiple myeloma.	Cfh13	Abundant plasma cells consistent with involvement by the patient's known myeloma.
Case 14	44F.	Iac0	HSIL. Nucleoli and keratinization raise the possibility of invasion • but diathesis is lacking.
Case 15	66 yo female with postmenopausal bleeding	Ndk6	Endometrial Adenocarcinoma
Case 16	40 year old woman. Routine screening pap. HPV +18.	Cfh13	Endocervical adenocarcinoma in situ. Confirmed on subsequent LEEP.
Case 17	79F. History of cervical cancer post chemoradiation.	Iac0	Reactive changes • consistent with radiation effect.
Case 18	25 yo woman. First screening pap.	Cfh13	LSIL.
Case 19	55yo post-menopausal with history of plasma cell myeloma. New • expanding cervical/adnexal mass. Pelvic exam reveals a cervix replaced by a large mass • mostly submucosal • with some central cervical invasion. Ultrasound reveals a left parametria extension of mass • measuring 6 cm.	Lr295	Plasmacytoma • poorly differentiated (stains CD138 + with monoclonal kappa light chain population).
Case 20	32 yo F at screening visit with no prior abnormal pap smears.	Cfh13	Negative for intraepithelial lesion or malignancy. Reactive changes. Cellular changes consistent with herpes simplex virus
Case 21	57 yo F status post TAH for endometrioid adenocarcinoma. Concurrent biopsy taken.	Cfh13	Epithelial cell abnormality - Glandular. Endometrial adenocarcinoma.
Case 22	44 year old - Pap 2021 ASCUS/+HPV 16 with negative colpo • now +HPV16	Est105	AIS
Case 23	26 yo F with an IUD and a history of LSIL and high-risk HPV.	Cfh13	Negative for intraepithelial lesion or malignancy. Pseudoactinomycotic radiate granule (PAMRAG).
Case 24	52 yo F with all prior pap negative and HPV negative.	Tz046	Negative pap. Transitional cell metaplasia in a background of atrophic changes.
Case 25	60 year old woman with postmenopausal bleeding	Mk213	Epithelial cell abnormality - glandular Atypical endometrial cells • favor neoplastic. Concurrent surgical endometrial biopsy: Endometroid adenocarcinoma • grade 2 of 3.
Case 26	hx LSIL	Est105	LSIL but also HSV
Case 27	34 yo F. All prior paps negative. HPV 16 and 45 positive.	Cfh13	ASCUS. Trichomonas vaginalis present. Asperity.
Case 28	67 yo F presenting for routine pap screening.	Cfh13	ASCUS. Cellular changes consistent with herpes simplex virus. Atrophic changes present. Acute inflammation.
Case 29	36 yo F with IUD on routine screening	Cfh13	Epithelial cell abnormality - glandular. Atypical endocervical cells • NOS.
Case 30	32 yo F with a prior AGUS pap	Cfh13	Endocervical adenocarcinoma in situ. Candida.
Case 31	28 yo F with intermenstrual bleeding	Cfh13	High grade squamous intraepithelial lesion
Case 32	30 YO • routine pap	Td693	Endocervical Adenocarcinoma is situ
Case 33	69F. Pap smear.	Iac0	Endometrial endometrioid adenocarcinoma.
Case 34	60F. Post menopausal.	Iac0	Adenocarcinoma.
Case 35	55F. History of colorectal adenocarcinoma.	Iac0	Extrauterine adenocarcinoma.
Case 36	49F	Mlz8	NILM reactive • concurrent biopsy lower uterine segment polyp
Case 37	29 yo F	Ndk6	Herpes simplex virus
Case 38	34F	Mlz8	HSV
Case 39	68F	Mlz8	Endometrial adenocarcinoma
Case 40	35 year old woman with history of squamous intraepithelial lesion	Njc35	High grade squamous intraepithelial lesion. Fungal organisms morphologically consistent with Candida species.
Case 41	24F • pregnant	Mlz8	Asperities (ASCUS)
Case 42	52 YO	Ndk6	Squamous Cell Carcinoma
Case 43	26 YO history of ASCUS • HPV neg	Ndk6	Low grade squamous intraepithelial lesion
Case 44	39 YO with history of dysplasia	Ndk6	Low grade squamous intraepithelial lesion.
Case 45	53 YO postmenopausal	Ndk6	NILM with tubal metaplasia
Case 46	53 yo F with history of TAH	Ndk6	Low grade squamous intraepithelial lesion
Case 47	47 yo F	Ndk6	NILM- fungal organisms consistent with Candida species present
Case 48	31 yo F. Screening pap smear.	Cfh13	Cytology: HSIL. Biopsy: Moderate squamous dysplasia.
Case 49	post Menopausal. ASH-H	Sxm	High-grade squamous dysplasia • probably with endocervical glandular involvement.
Case 50	AIN2 s/p HYF 12/2022	Sxm	Epithelial Cell Abnormality - Squamous: High grade squamous intraepithelial lesion.
Case 51	72 yo female	Dc679	A. CERVICAL • LIQUID BASED SPECIMEN: SPECIMEN ADEQUACY: Satisfactory for evaluation. INTERPRETATION: EPITHELIAL CELL ABNORMALITY - GLANDULAR. Endometrial adenocarcinoma. ADDITIONAL INFORMATION: This specimen was prescreened using the BD FocalPoint GS Imaging System.
Case 52	48 yo female	Dc679	A. CERVICAL • LIQUID BASED SPECIMEN: SPECIMEN ADEQUACY: Satisfactory for evaluation. INTERPRETATION: EPITHELIAL CELL ABNORMALITY - SQUAMOUS. High grade squamous intraepithelial lesion with features concerning for invasion. ADDITIONAL INFORMATION: This specimen was prescreened using the BD FocalPoint GS Imaging System.
Case 53	32 yo F	Ndk6	ASCUS and trichomonas vaginalis • actinomyces species • and candida species.
Case 54	22 yo f	Ndk6	LSIL
Case 55	42F	Mlz8	ASCUS (asperites)
Case 56	42F	Mlz8	ASCUS atypical repair
Case 57	62 yo woman with cervical friability	Lt511	High grade squamous intraepithelial lesion. Invasive squamous cell carcinoma cannot be excluded
Case 58	45F. History of LSIL. Mirena IUD.	Iac0	LSIL. IUD effect. HPV-negative.
Case 59	70 yo f w/ recurrent ovarian cancer with friable vaginal mass	Ndk6	EPITHELIAL CELL ABNORMALITY - GLANDULAR. Malignant neoplasm with features consistent with patient’s known malignant mixed mesodermal tumor.
Case 60	62 yo f w/ vulvar mass	Ndk6	Squamous cell carcinoma
Case 139	67 yo F	Ndk6	High grade squamous intraepithelial lesion
Case 140	74 yo f w/ postmenopausal bleeding • endometrial stripe thickening • and a 2.8 cm endocervical mass	Ndk6	Adenocarcinoma Bx: Endometrial serous carcinoma
Case 141	48 yo f w/ IUD	Ndk6	NILM- endometrial cells >45 • trichomonas vaginalis • actinomyces • and reactive cellular changes consistent with IUD effect
Case 142	21-year-old woman with recent pelvic pain presents for first pap smear	Ez278	Negative for intraepithelial lesion or malignancy. Cellular changes consistent with herpes simplex virus.
Case 143	34-year-old M with history of AIN 2-3 and HSIL anal pap s/p HYF. High-risk HPV positive.	Ez278	High grade squamous intraepithelial lesion (HSIL)
Case 144	40F • cervical pap	Mlz8	NILM • Trichomonas
Case 145	75 years old woman with postmenopausal bleeding	Lt511	Endometrial adenocarcinoma
Case 146	35-year-old woman • HPV negative	Lt511	HSIL
Case 147	Trichomonas	Sxm	Trichomonas
Case 148	Herpes	Sxm	Herpes
Case 149	40 yo F. Screening pap.	Ndk6	NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY- Trichomonas vaginalis
Case 150	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 152	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 153	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 155	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 156	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 158	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 159	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 161	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 162	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 164	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 165	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 167	36 yo F positive for HPV 16	Ndk6	High grade squamous intraepithelial lesion.
Case 168	21 yo F w/ IUD	Ndk6	Low grade squamous intraepithelial lesion and Trichomonas vaginalis
Case 169	74 yo F w/ PMB	Ndk6	Endometrial adenocarcinoma
Case 170	62 yo F	Ndk6	NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY- Follicular cervicitis
Case 171	74 yo F presenting with post menopausal bleeding and friable cervix	Ndk6	Endometrial adenocarcinoma
Case 172	36 yo HPV 16+	Ndk6	High grade squamous intraepithelial lesion
Case 173	41 yo Cervical high risk HPV +16	Ndk6	Endocervical adenocarcinoma • at least in-situ.