Difference between revisions of "mgh:cyto-week1-5"
From MGH Learn Pathology
(Created page with "''GYN Glandular Lesions'' Week 1 * Content Expert: David C. Wilbur, MD * Cytotechnologist: Peter Brown * Objective: To describe the common morphologic features in glandular ce...") |
|||
| Line 1: | Line 1: | ||
| − | ''GYN Glandular Lesions'' | + | '''GYN Glandular Lesions''' |
| + | <br> | ||
Week 1 | Week 1 | ||
* Content Expert: David C. Wilbur, MD | * Content Expert: David C. Wilbur, MD | ||
| Line 8: | Line 9: | ||
* [https://hub.partners.org/file/12487829/Glandular_Lesions_of_the_Cervix_Dr_Wilbur.pdf Glandular Lesions of the Cervix - Dr. Wilbur] | * [https://hub.partners.org/file/12487829/Glandular_Lesions_of_the_Cervix_Dr_Wilbur.pdf Glandular Lesions of the Cervix - Dr. Wilbur] | ||
* [https://hub.partners.org/file/12487831/GynCyto_EFB.pdf Gyn Cyto - Dr. Brachtel] | * [https://hub.partners.org/file/12487831/GynCyto_EFB.pdf Gyn Cyto - Dr. Brachtel] | ||
| − | + | <br> | |
Normal endocervicals – MG07-41719 | Normal endocervicals – MG07-41719 | ||
* Column cells with basally located nuclei | * Column cells with basally located nuclei | ||
| Line 14: | Line 15: | ||
* Picket fence arrangement when seen on side, honeycomb when seen from above | * Picket fence arrangement when seen on side, honeycomb when seen from above | ||
* Nuclei round, oval, slightly larger than em nuclei, similar to sq. met. | * Nuclei round, oval, slightly larger than em nuclei, similar to sq. met. | ||
| − | + | <br> | |
Normal endometrial cells – MG07-37747 | Normal endometrial cells – MG07-37747 | ||
* Nuclei small, round, dark, indistinct nucleoli | * Nuclei small, round, dark, indistinct nucleoli | ||
| Line 21: | Line 22: | ||
* Superficial stromal cells look like histocytes | * Superficial stromal cells look like histocytes | ||
* 3-D ball like clusters | * 3-D ball like clusters | ||
| − | + | <br> | |
Reactive endocervicals – C02-X21800 | Reactive endocervicals – C02-X21800 | ||
* Slightly to moderately enlarged nuclear size | * Slightly to moderately enlarged nuclear size | ||
| Line 29: | Line 30: | ||
* Nuclear contours regular | * Nuclear contours regular | ||
* In groups cells maintain polarity | * In groups cells maintain polarity | ||
| − | + | <br> | |
Endocervical atypia 10D –C92-1561 and MG09-21470 | Endocervical atypia 10D –C92-1561 and MG09-21470 | ||
* Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle | * Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle | ||
| Line 35: | Line 36: | ||
* Normal or slightly irregular ems with vacuoles | * Normal or slightly irregular ems with vacuoles | ||
* Actinomyces | * Actinomyces | ||
| − | + | <br> | |
Tubal metaplasia – G11-37675 | Tubal metaplasia – G11-37675 | ||
* Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia | * Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia | ||
* Nuclei can be round or oval | * Nuclei can be round or oval | ||
* Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS) | * Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS) | ||
| − | + | <br> | |
AIS endocervical – MG06-00971 and C01-D39098 | AIS endocervical – MG06-00971 and C01-D39098 | ||
* Columnar cells in crowded groups, strips on rosettes | * Columnar cells in crowded groups, strips on rosettes | ||
| Line 46: | Line 47: | ||
* Peripheral nuclear palisading (feathering) | * Peripheral nuclear palisading (feathering) | ||
* Irregular dark chromatin, nuclear enlargement | * Irregular dark chromatin, nuclear enlargement | ||
| − | + | <br> | |
Endocervial Adenoca – MG09-31908 | Endocervial Adenoca – MG09-31908 | ||
* Ec’s with enlarged hyperchromatic nuclei in strips | * Ec’s with enlarged hyperchromatic nuclei in strips | ||
| Line 52: | Line 53: | ||
* Loss of polarity | * Loss of polarity | ||
* Difficult to differentiate from AIS | * Difficult to differentiate from AIS | ||
| − | + | <br> | |
Endocervical Adenoca – C98-17153 | Endocervical Adenoca – C98-17153 | ||
* Strips, rosettes, feathering | * Strips, rosettes, feathering | ||
| Line 62: | Line 63: | ||
* Mitosis | * Mitosis | ||
* Diasisis | * Diasisis | ||
| − | + | <br> | |
Endometrial CA Grade III – C02-R1948 | Endometrial CA Grade III – C02-R1948 | ||
* Ball like and papillary groups of irregular glandular cells | * Ball like and papillary groups of irregular glandular cells | ||
| Line 68: | Line 69: | ||
* Prominent nucleoli | * Prominent nucleoli | ||
* Watery tumor diathesis | * Watery tumor diathesis | ||
| − | + | <br> | |
Metastatic ovarian adenocarcinoma – C02-N42569 | Metastatic ovarian adenocarcinoma – C02-N42569 | ||
* Papillary architecture | * Papillary architecture | ||
Revision as of 13:59, June 23, 2020
GYN Glandular Lesions
Week 1
- Content Expert: David C. Wilbur, MD
- Cytotechnologist: Peter Brown
- Objective: To describe the common morphologic features in glandular cell lesions found in pap smears.
Related PDFs of Lectures
Normal endocervicals – MG07-41719
- Column cells with basally located nuclei
- Basophilic vacuolated cytoplasm
- Picket fence arrangement when seen on side, honeycomb when seen from above
- Nuclei round, oval, slightly larger than em nuclei, similar to sq. met.
Normal endometrial cells – MG07-37747
- Nuclei small, round, dark, indistinct nucleoli
- Cytoplasm is scant, may have vacuoles
- Deep stromal cells, dark, degenerate with scant cytoplasm
- Superficial stromal cells look like histocytes
- 3-D ball like clusters
Reactive endocervicals – C02-X21800
- Slightly to moderately enlarged nuclear size
- Prominent nucleoli
- Can see multinucleation
- Chromatin normal
- Nuclear contours regular
- In groups cells maintain polarity
Endocervical atypia 10D –C92-1561 and MG09-21470
- Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle
- Single cells or small clusters of reaction endocervicals
- Normal or slightly irregular ems with vacuoles
- Actinomyces
Tubal metaplasia – G11-37675
- Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia
- Nuclei can be round or oval
- Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS)
AIS endocervical – MG06-00971 and C01-D39098
- Columnar cells in crowded groups, strips on rosettes
- Strips may have pseudostratification, groups with irregular polarity
- Peripheral nuclear palisading (feathering)
- Irregular dark chromatin, nuclear enlargement
Endocervial Adenoca – MG09-31908
- Ec’s with enlarged hyperchromatic nuclei in strips
- Rosettes, pseudostratification, feathering
- Loss of polarity
- Difficult to differentiate from AIS
Endocervical Adenoca – C98-17153
- Strips, rosettes, feathering
- Disorderly arrangement
- High N/C ratio
- Coarse chromatin
- Architectural features similar to AIS but with greater loss of polarity
- Prominent nucleoli
- Mitosis
- Diasisis
Endometrial CA Grade III – C02-R1948
- Ball like and papillary groups of irregular glandular cells
- Nuclear contour irregularities
- Prominent nucleoli
- Watery tumor diathesis
Metastatic ovarian adenocarcinoma – C02-N42569
- Papillary architecture
- Nuclear enlargement
- Crowding
- Loss of polarity
- Psammoma bodies may be present
