Difference between revisions of "DZI19-179-Case-11"
From MGH Learn Pathology
(Created page with "{{dziSlide |order_date=November 04, 2019 06:55:57 PM |user=Em99 |slide_anatomy=Show |dzi_filename=DZI19-67-Case-25_1 }} {{dziCase |order_date=November 04, 2019 06:55:57 PM |us...") |
|||
| Line 11: | Line 11: | ||
|case_id=11 | |case_id=11 | ||
|publish_timestamp=Choose_date 13:00 | |publish_timestamp=Choose_date 13:00 | ||
| + | |clinical_hx=48yo woman with solitary thyroid nodule | ||
|case_diagnosis=MALIGNANT: Medullary carcinoma of thyroid | |case_diagnosis=MALIGNANT: Medullary carcinoma of thyroid | ||
| + | |case_notes=Markedly cellular smear | ||
| + | Numerous isolated cells, most of which are plasmacytoid | ||
| + | Rare bizarre giant cells are seen | ||
| + | Binucleation is common | ||
| + | Cytoplasm is granular; small red-purple granules are seen in DQ and rare cases may show melanin pigment | ||
| + | |||
| + | IHC will help: | ||
| + | Positive = CT, CEA, NE markers, TTF1, PAX8, congo red | ||
| + | Negative = TG | ||
| + | |||
| + | MTC occurs in sporadic and heritable forms. | ||
| + | Sporadic MTC (70-80% of cases) typically presents as a SOLITARY thyroid nodule in adults. | ||
| + | |||
| + | Patients with hereditary MTC usually develop multifocal bilateral thyroid tumors, and the age of presentation varies with the syndrome. Hereditary syndromes include Multiple Endocrine Neoplasia (MEN) type 2A, familial medullary thyroid carcinoma, and MEN type 2B. | ||
| + | |||
| + | MEN2 and FMTC show an AUTOSOMAL DOMINANT mode of inheritance and are associated with pathogenic germline mutations of the RET gene, encoded on chromosome 10, that result in constitutive activation of the RET receptor tyrosine kinase. | ||
}} | }} | ||
Revision as of 10:50, November 12, 2019
No results
No resultsNo results
No resultsNo results
