Difference between revisions of "DZI19-179-Case-3"
From MGH Learn Pathology
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|case_id=3 | |case_id=3 | ||
|publish_timestamp=Choose_date 13:00 | |publish_timestamp=Choose_date 13:00 | ||
| + | |clinical_hx=40yo woman with a diffuse (not nodular) enlargement of the thyroid gland. A a radioactive iodine uptake test revealed a large cold nodule (does not produce thyroid hormone). | ||
|case_diagnosis=ATYPIA OF UNDETERMINED SIGNIFICANCE (AUS): Surgical follow-up: Graves disease | |case_diagnosis=ATYPIA OF UNDETERMINED SIGNIFICANCE (AUS): Surgical follow-up: Graves disease | ||
| + | |case_notes=Cellular aspirate with a variable number of follicular cells, with occasional lymphocytes scattered in the background. Follicular cells are arranged in flat sheets and loosely cohesive groups, with ABUNDANT DELICATE, FOAMY CYTOPLASM. Many nuclei are enlarged, vesicular, and show prominent nucleoli. Anisonucleosis is prominent, and cytoplasm has a granular, "ONCOCYTOID" appearance. | ||
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| + | "Flame cells" may be prominent are represented by marginal cytoplasmic vacuoles with red to pinked frayed edges (base seen with DQ stain). Flame cells are not specific for GD, and may be encountered in other non-neoplastic thyroid conditions, follicular neoplasms, and PTC. | ||
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| + | Occasionally, treated GD shows prominent microfollicular architecture, significant nuclear overlapping and crowding, and considerable ANISONUCLEOSIS. One should look into whether or not the patient has had RADIOACTIVE IDOINE THERAPY, to not over-interpret these findings. | ||
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Revision as of 10:06, November 12, 2019
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