Difference between revisions of "DZI19-121-Case-1"
From MGH Learn Pathology
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|publish_timestamp=2019/09/13 19:00 | |publish_timestamp=2019/09/13 19:00 | ||
|clinical_hx=63 year old woman with a history of breast CA s/p bilateral mastectomy presents with difficulty walking, staggering gait, and fatigue | |clinical_hx=63 year old woman with a history of breast CA s/p bilateral mastectomy presents with difficulty walking, staggering gait, and fatigue | ||
| − | |case_diagnosis= | + | |case_diagnosis=Integrated diagnosis: GLIOBLASTOMA, IDH-WILDTYPE |
| + | |||
| + | Histological diagnosis: Glioblastoma | ||
| + | |||
| + | WHO histological grade: IV | ||
| + | |||
| + | Molecular information: | ||
| + | IDH1: negative (R132H immunohistochemistry) | ||
| + | MGMT promoter: methylated (methylation specific PCR) | ||
IHC for mutant ID1(R132H) was negative and is sufficient in patients >55 years of age to determine IDH status (rare to find non-canonical mutations in this group). | IHC for mutant ID1(R132H) was negative and is sufficient in patients >55 years of age to determine IDH status (rare to find non-canonical mutations in this group). | ||
Revision as of 20:30, September 13, 2019
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