Difference between revisions of "DZI19-121-Case-7"
From MGH Learn Pathology
(Edited automatically from page DZI19-121.) |
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|order_date=September 11, 2019 01:58:15 PM | |order_date=September 11, 2019 01:58:15 PM | ||
|user=Em99 | |user=Em99 | ||
| + | |slide_stain=H&E | ||
|slide_anatomy=Show | |slide_anatomy=Show | ||
}} | }} | ||
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|order_date=September 11, 2019 01:58:15 PM | |order_date=September 11, 2019 01:58:15 PM | ||
|user=Em99 | |user=Em99 | ||
| + | |slide_stain=MUTANT BRAF V600E | ||
|slide_anatomy=Show | |slide_anatomy=Show | ||
}} | }} | ||
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|case_id=7 | |case_id=7 | ||
|clinical_hx=23 year old woman with deep left cerebellar mass discovered incidentally on an MRI of the cervical spine obtained after a motor vehicle accident. | |clinical_hx=23 year old woman with deep left cerebellar mass discovered incidentally on an MRI of the cervical spine obtained after a motor vehicle accident. | ||
| + | |case_diagnosis=Integrated diagnosis: | ||
| + | DIFFUSE GLIOMA, BRAF V600E-MUTANT | ||
| + | |||
| + | Histological diagnosis: Diffuse astrocytoma | ||
| + | |||
| + | WHO (integrated histological and molecular) grade: undefined (likely II) | ||
| + | |||
| + | Molecular information: | ||
| + | BRAF V600E: MUTANT (immunohistochemistry and sequencing) | ||
| + | IDH: wildtype (IDH1/2 sequencing) | ||
| + | P53: weak in rare tumor cells (immunohistochemistry, consistent with wildtype) | ||
| + | ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype) | ||
| + | MGMT promoter: methylated (PCR) | ||
| + | EGFR gene amplification: absent (FISH) | ||
| + | }} | ||
| + | {{dziReference | ||
| + | |order_date=September 14, 2019 01:45:26 AM | ||
| + | |user=Mml55 | ||
| + | |pubmed=30848347 | ||
}} | }} | ||
Revision as of 20:47, September 13, 2019
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