Difference between revisions of "DZI19-121-Case-5"
From MGH Learn Pathology
(Edited automatically from page DZI19-121.) |
|||
| Line 2: | Line 2: | ||
|order_date=September 11, 2019 01:58:00 PM | |order_date=September 11, 2019 01:58:00 PM | ||
|user=Em99 | |user=Em99 | ||
| + | |slide_stain=H&E | ||
|slide_anatomy=Show | |slide_anatomy=Show | ||
}} | }} | ||
| Line 7: | Line 8: | ||
|order_date=September 11, 2019 01:58:00 PM | |order_date=September 11, 2019 01:58:00 PM | ||
|user=Em99 | |user=Em99 | ||
| + | |slide_stain=Mutant H3K27M | ||
|slide_anatomy=Show | |slide_anatomy=Show | ||
}} | }} | ||
| Line 18: | Line 20: | ||
|case_id=5 | |case_id=5 | ||
|clinical_hx=38 y.o. woman with a 2 month hx of positional vertigo, L facial weakness, tinnitus, and left anterior tongue numbness | |clinical_hx=38 y.o. woman with a 2 month hx of positional vertigo, L facial weakness, tinnitus, and left anterior tongue numbness | ||
| + | |case_diagnosis=Integrated diagnosis: | ||
| + | DIFFUSE MIDLINE GLIOMA, H3K27M-MUTANT | ||
| + | |||
| + | Histological diagnosis: Anaplastic astrocytoma | ||
| + | |||
| + | WHO (integrated histological and molecular) grade: IV | ||
| + | |||
| + | Molecular information: | ||
| + | H3K27M: MUTANT (immunohistochemistry) | ||
| + | IDH: wildtype (IDH1/2 PCR sequencing) | ||
| + | P53: negative in tumor cells (immunohistochemistry, consistent with wildtype) | ||
| + | ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype) | ||
| + | MGMT promoter: unmethylated (methylation specific PCR) | ||
| + | }} | ||
| + | {{dziReference | ||
| + | |order_date=September 14, 2019 01:38:42 AM | ||
| + | |user=Mml55 | ||
| + | |pubmed=29497819 | ||
| + | }} | ||
| + | {{dziReference | ||
| + | |order_date=September 14, 2019 01:38:42 AM | ||
| + | |user=Mml55 | ||
}} | }} | ||
Revision as of 20:40, September 13, 2019
No results
No resultsNo results
No resultsNo results
