Difference between revisions of "DZI19-121-Case-4"
From MGH Learn Pathology
(Edited automatically from page DZI19-121.) |
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|case_id=4 | |case_id=4 | ||
|clinical_hx=67 year old man with new onset of seizures | |clinical_hx=67 year old man with new onset of seizures | ||
| + | |case_diagnosis=Integrated diagnosis: | ||
| + | DIFFUSE ASTROCYTIC GLIOMA, IDH-WILDTYPE, WITH MOLECULAR FEATURES OF GLIOBLASTOMA | ||
| + | |||
| + | Histological diagnosis: Anaplastic astrocytoma | ||
| + | |||
| + | WHO (integrated histological and molecular grade): IV | ||
| + | |||
| + | Molecular information: | ||
| + | IDH: wildtype (IDH1/2 PCR sequencing) | ||
| + | P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) | ||
| + | ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype) | ||
| + | MGMT promoter: unmethylated (methylation specific PCR) | ||
| + | EGFR amplification: PRESENT (FISH) | ||
| + | }} | ||
| + | {{dziReference | ||
| + | |order_date=September 14, 2019 01:32:36 AM | ||
| + | |user=Mml55 | ||
| + | |pubmed=30259105 | ||
| + | }} | ||
| + | {{dziReference | ||
| + | |order_date=September 14, 2019 01:32:36 AM | ||
| + | |user=Mml55 | ||
}} | }} | ||
Revision as of 20:34, September 13, 2019
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