WSI21-129

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Subspecialty Cytology

Set Cytology

Topic Thyroid

Presenter MGH

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Toggle columns: Diagnosis

Case	Clinical history	Requester	Diagnosis
Case	Clinical history	Requester	Diagnosis
Case 1	51M small nodule on US.	Iac0	Medullary thyroid carcinoma
Case 2	92F with large left thyroid nodule	Mlz8	Suspicious for Hurthle cell neoplasm
Case 3	57 year-old male. Nodule inferior to thyroid.	Iac0	Parathyroid tissue.
Case 4	76yo female with thyroid nodules	Mlz8	Hashimoto thyroiditis (part A); Papillary thyroid carcinoma arising in Hashimoto thyroiditis (part B)
Case 5	66 year old woman with a 1.6 cm thyroid nodule	Lz17	Hurthle cell neoplasm (note: serum calcitonin levels undetectable)
Case 6	46yo female with right thyroid nodule	Mlz8	Medullary thyroid carcinoma
Case 7	16M. Thyroid nodule.	Iac0	AUS. Thyroid follicular cells with macrofollicular architecture and focal nuclear atypia. Thyroseq with DICER1 mutation.
Case 8	70M. Thyroid mass.	Iac0	Anaplastic thyroid carcinoma.
Case 9	29 year old F with a 2 cm thyroid nodule.	Cfh13	Positive for malignant cells: Papillary thyroid carcinoma.
Case 10	48F. History of thyroid carcinoma. New lung mass.	Iac0	Metastatic thyroid follicular carcinoma with oncocytic (Hurthle cell) features.
Case 11	77yo woman with 3.3cm right thyroid nodule	Ez278	Medullary thyroid carcinoma
Case 12	75 yo F with multi-nodular goiter. Largest nodule 2 cm.	Cfh13	Suspicious for Hurthle Cell neoplasm (Bethesda Category IV)
Case 13	78 yo F with longstanding thyroid nodule with a recent rapid increase in size.	Cfh13	Positive for anaplastic thyroid carcinoma.
Case 14	73 year old F with prior thyroidectomy and current flank mass sampled in the FNA clinic.	Lcm51	Metastatic follicular thyroid carcinoma with high grade features.
Case 15	72F. 2.7 cm thyroid mass.	Iac0	Medullary thyroid carcinoma.
Case 16	70 yo F with a new 2 cm thyroid nodule.	Cfh13	Initial sign-out: Positive for malignant cells. Papillary carcinoma. Subsequent surgical specimen: Tubular adenoma.
Case 17	78 yo F with a growing thyroid nodule.	Cfh13	Suspicious for a Hurthle cell (oncocytic) neoplasm (Bethesda Category IV). Thyroseq: Negative.
Case 18	26 yo F with an incidental thyroid nodule	Cfh13	Suspicious for a follicular neoplasm (Bethesda category IV). Cellular microfollicular lesion • suspicious for a follicular neoplasm.
Case 19	45 yo female with 8 mm nodule	Ndk6	Papillary thyroid carcinoma • follicular variant
Case 20	40ish year old woman with history of thyroid tumor.	Tlh39	Metastatic medullary thyroid carcinoma.
Case 21	76 up man with a thyroid nodule	Cfh13	Papillary carcinoma with abundant cystic degeneration
Case 22	34F • right thyroid nodule	Mlz8	Suspicious for Hurthle cell neoplasm
Case 23	24F • left neck mass	Mlz8	Papillary thyroid carcinoma
Case 24	51 yo female	Dc679	PTC in background of HASH
Case 25	41 yo female	Dc679	Hashimoto thyroiditis
Case 26	47 yo male	Dc679	Medullary Thyroid carcinoma
Case 27	57 yo female	Dc679	Papillary Thyroid Carcinoma
Case 28	44 years old woman with thyroid nodule	Lt511	granulomatous thyroiditis
Case 29	57F • thyroid nodule.	Iac0	Follicular neoplasm • oncocytic type.
Case 30	73 yo male • right neck	Ndk6	Metastatic papillary thyroid carcinoma
Case 31	35 yo female • 24 mm thyroid nodule	Ndk6	Malignant cells present • cytomorphologically suggestive of cystic variant of papillary thyroid carcinoma
Case 32	52 yo female • mid/lower pole nodule • solid • very hypoechoic • irregular borders- 10mm	Ndk6	Papillary thyroid carcinoma
Case 33	37 yo female • treated thyroid cancer; FDG+ mass	Ndk6	Neuroendocrine tumor consistent with recurrence of the patient’s known neuroendocrine carcinoma
Case 34	53 yo male • left thyroid nodule • solid • heterogeneous with coarse calcifications; 28mm	Ndk6	Oncocytic neoplasm with widespread nuclear atypia • favor oncocytic papillary thyroid carcinoma
Case 35	66 yo M w/ 20 mm thyroid nodule	Ndk6	Papillary thyroid carcinoma
Case 36	47 yo F w/ thyroid nodule	Ndk6	Papillary thyroid carcinoma
Case 37	39 yo F isolated • 1.5 cm right thyroid nodule	Ndk6	Granulomatous thyroiditis
Case 38	75 yo F • history of multiple myeloma • remission status unknown	Ndk6	POSITIVE FOR MALIGNANT CELLS Consistent with involvement by the patient’s known plasma cell myeloma Note: Immunohistochemistry shows that the tumor cells are positive for CD138 (patchy) and MUM1. They are negative for PAX8 • calcitonin • and S100.