Difference between revisions of "mgh:cyto-1-13"
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| − | + | __NOCACHE__{{DISPLAYTITLE:1-13 Adrenal: R Tambouret MD, E Brachtel MD, R Arpin CT}}{{:TOC}} | |
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* Indications for cytology examination | * Indications for cytology examination | ||
* Procuring the specimen | * Procuring the specimen | ||
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<br> | <br> | ||
| − | + | == Basic cytomorphology == | |
| − | + | {{collapsed| | |
| − | + | '''Normal adrenal cells – N13-6084'''| | |
| − | '''Normal adrenal cells – N13-6084''' | ||
* Variable Cellularity | * Variable Cellularity | ||
* Cortex: | * Cortex: | ||
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** Large eccentric nucleus with fine chromatin | ** Large eccentric nucleus with fine chromatin | ||
** Conspicuous nucleoli | ** Conspicuous nucleoli | ||
| − | + | ||
Adrenal cortical nodules (hyperplastic, adenomas) | Adrenal cortical nodules (hyperplastic, adenomas) | ||
* Usually indistinguishable from benign cortical cells | * Usually indistinguishable from benign cortical cells | ||
| − | + | |}} | |
| − | + | {{collapsed| | |
| − | '''Pheochromocytoma – C91-C20757''' | + | '''Pheochromocytoma – C91-C20757'''| |
* Loosely cohesive round/plasmacytoid to spindled cells | * Loosely cohesive round/plasmacytoid to spindled cells | ||
* Fibrillary cytoplasm, oval hyperchromatic nuclei - may show anisonucleosis/pleomorphism/binucleation | * Fibrillary cytoplasm, oval hyperchromatic nuclei - may show anisonucleosis/pleomorphism/binucleation | ||
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* Synaptophysin, chromogranin positive; S-100 positive in spindle cells | * Synaptophysin, chromogranin positive; S-100 positive in spindle cells | ||
* MIMICS: Adrenal cortical carcinoma, other poorly differentiated malignancies | * MIMICS: Adrenal cortical carcinoma, other poorly differentiated malignancies | ||
| − | + | |}} | |
| − | + | {{collapsed| | |
| − | '''Adrenal cortical carcinoma – C99-T12804''' | + | '''Adrenal cortical carcinoma – C99-T12804'''| |
* May not be able to diagnose on cytology alone, but may suspect if mitoses, necrosis or marked pleomorphism is present | * May not be able to diagnose on cytology alone, but may suspect if mitoses, necrosis or marked pleomorphism is present | ||
Histological assessment required to distinguish larger adenomas from carcinomas | Histological assessment required to distinguish larger adenomas from carcinomas | ||
| − | + | |}} | |
| − | + | {{collapsed| | |
| − | '''Metastases –N13-6638, C95-N3969 and C97-R25603''' | + | '''Metastases –N13-6638, C95-N3969 and C97-R25603'''| |
* cell population resembling primary tumor | * cell population resembling primary tumor | ||
| + | |}} | ||
| + | {{:mgh:cytology-footer}} | ||
Latest revision as of 14:43, July 2, 2020
Contents
- Indications for cytology examination
- Procuring the specimen
- Test platforms/specimen processing and triage
- Report
Basic cytomorphology
Normal adrenal cells – N13-6084
- Variable Cellularity
- Cortex:
- Bare nuclei with foamy lipid from stripped cytoplasm background
- Single cells with round nuclei, inapparent nucleoli
- In intact cells, abundant vacuolated cytoplasm with frayed edges
- Medulla
- Rarely sampled, cells have basophilic cytoplasm
- Large eccentric nucleus with fine chromatin
- Conspicuous nucleoli
Adrenal cortical nodules (hyperplastic, adenomas)
- Usually indistinguishable from benign cortical cells
Pheochromocytoma – C91-C20757
- Loosely cohesive round/plasmacytoid to spindled cells
- Fibrillary cytoplasm, oval hyperchromatic nuclei - may show anisonucleosis/pleomorphism/binucleation
- Melanin pigment in some cells
- Red cytoplasmic granularity on air dried material
- Synaptophysin, chromogranin positive; S-100 positive in spindle cells
- MIMICS: Adrenal cortical carcinoma, other poorly differentiated malignancies
Adrenal cortical carcinoma – C99-T12804
- May not be able to diagnose on cytology alone, but may suspect if mitoses, necrosis or marked pleomorphism is present
Histological assessment required to distinguish larger adenomas from carcinomas
Metastases –N13-6638, C95-N3969 and C97-R25603
- cell population resembling primary tumor
