Difference between revisions of "mgh:cyto-week1-5"
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(Created page with "''GYN Glandular Lesions'' Week 1 * Content Expert: David C. Wilbur, MD * Cytotechnologist: Peter Brown * Objective: To describe the common morphologic features in glandular ce...") |
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| − | + | __NOCACHE__{{DISPLAYTITLE:1-3 GYN Cytomorphology- Glandular}}{{:TOC}} | |
| − | Week 1 | + | == Week 1 == |
* Content Expert: David C. Wilbur, MD | * Content Expert: David C. Wilbur, MD | ||
* Cytotechnologist: Peter Brown | * Cytotechnologist: Peter Brown | ||
* Objective: To describe the common morphologic features in glandular cell lesions found in pap smears. | * Objective: To describe the common morphologic features in glandular cell lesions found in pap smears. | ||
| − | + | == Related PDFs of Lectures == | |
| − | Related PDFs of Lectures | ||
* [https://hub.partners.org/file/12487829/Glandular_Lesions_of_the_Cervix_Dr_Wilbur.pdf Glandular Lesions of the Cervix - Dr. Wilbur] | * [https://hub.partners.org/file/12487829/Glandular_Lesions_of_the_Cervix_Dr_Wilbur.pdf Glandular Lesions of the Cervix - Dr. Wilbur] | ||
* [https://hub.partners.org/file/12487831/GynCyto_EFB.pdf Gyn Cyto - Dr. Brachtel] | * [https://hub.partners.org/file/12487831/GynCyto_EFB.pdf Gyn Cyto - Dr. Brachtel] | ||
| − | + | <br> | |
| − | Normal endocervicals – MG07-41719 | + | {{collapsed| |
| + | Normal endocervicals – MG07-41719| | ||
* Column cells with basally located nuclei | * Column cells with basally located nuclei | ||
* Basophilic vacuolated cytoplasm | * Basophilic vacuolated cytoplasm | ||
* Picket fence arrangement when seen on side, honeycomb when seen from above | * Picket fence arrangement when seen on side, honeycomb when seen from above | ||
| − | * Nuclei round, oval, slightly larger than em nuclei, similar to sq. met. | + | * Nuclei round, oval, slightly larger than em nuclei, similar to sq. met. <br><br> |
| − | + | |}} | |
| − | Normal endometrial cells – MG07-37747 | + | {{collapsed| |
| + | Normal endometrial cells – MG07-37747| | ||
* Nuclei small, round, dark, indistinct nucleoli | * Nuclei small, round, dark, indistinct nucleoli | ||
* Cytoplasm is scant, may have vacuoles | * Cytoplasm is scant, may have vacuoles | ||
* Deep stromal cells, dark, degenerate with scant cytoplasm | * Deep stromal cells, dark, degenerate with scant cytoplasm | ||
* Superficial stromal cells look like histocytes | * Superficial stromal cells look like histocytes | ||
| − | * 3-D ball like clusters | + | * 3-D ball like clusters <br><br> |
| − | + | |}} | |
| − | Reactive endocervicals – C02-X21800 | + | {{collapsed| |
| + | Reactive endocervicals – C02-X21800| | ||
* Slightly to moderately enlarged nuclear size | * Slightly to moderately enlarged nuclear size | ||
* Prominent nucleoli | * Prominent nucleoli | ||
| Line 28: | Line 30: | ||
* Chromatin normal | * Chromatin normal | ||
* Nuclear contours regular | * Nuclear contours regular | ||
| − | * In groups cells maintain polarity | + | * In groups cells maintain polarity <br><br> |
| − | + | |}} | |
| − | Endocervical atypia 10D –C92-1561 and MG09-21470 | + | {{collapsed| |
| + | Endocervical atypia 10D –C92-1561 and MG09-21470| | ||
* Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle | * Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle | ||
* Single cells or small clusters of reaction endocervicals | * Single cells or small clusters of reaction endocervicals | ||
* Normal or slightly irregular ems with vacuoles | * Normal or slightly irregular ems with vacuoles | ||
| − | * Actinomyces | + | * Actinomyces <br><br> |
| − | + | |}} | |
| − | Tubal metaplasia – G11-37675 | + | {{collapsed| |
| + | Tubal metaplasia – G11-37675| | ||
* Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia | * Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia | ||
* Nuclei can be round or oval | * Nuclei can be round or oval | ||
| − | * Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS) | + | * Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS)<br><br> |
| − | + | |}} | |
| − | AIS endocervical – MG06-00971 and C01-D39098 | + | {{collapsed| |
| + | AIS endocervical – MG06-00971 and C01-D39098| | ||
* Columnar cells in crowded groups, strips on rosettes | * Columnar cells in crowded groups, strips on rosettes | ||
* Strips may have pseudostratification, groups with irregular polarity | * Strips may have pseudostratification, groups with irregular polarity | ||
* Peripheral nuclear palisading (feathering) | * Peripheral nuclear palisading (feathering) | ||
| − | * Irregular dark chromatin, nuclear enlargement | + | * Irregular dark chromatin, nuclear enlargement <br><br> |
| − | + | |}} | |
| − | Endocervial Adenoca – MG09-31908 | + | {{collapsed| |
| + | Endocervial Adenoca – MG09-31908| | ||
* Ec’s with enlarged hyperchromatic nuclei in strips | * Ec’s with enlarged hyperchromatic nuclei in strips | ||
* Rosettes, pseudostratification, feathering | * Rosettes, pseudostratification, feathering | ||
* Loss of polarity | * Loss of polarity | ||
| − | * Difficult to differentiate from AIS | + | * Difficult to differentiate from AIS <br><br> |
| − | + | |}} | |
| − | Endocervical Adenoca – C98-17153 | + | {{collapsed| |
| + | Endocervical Adenoca – C98-17153| | ||
* Strips, rosettes, feathering | * Strips, rosettes, feathering | ||
* Disorderly arrangement | * Disorderly arrangement | ||
| Line 61: | Line 68: | ||
* Prominent nucleoli | * Prominent nucleoli | ||
* Mitosis | * Mitosis | ||
| − | * Diasisis | + | * Diasisis <br><br> |
| − | + | |}} | |
| − | Endometrial CA Grade III – C02-R1948 | + | {{collapsed| |
| + | Endometrial CA Grade III – C02-R1948| | ||
* Ball like and papillary groups of irregular glandular cells | * Ball like and papillary groups of irregular glandular cells | ||
* Nuclear contour irregularities | * Nuclear contour irregularities | ||
* Prominent nucleoli | * Prominent nucleoli | ||
| − | * Watery tumor diathesis | + | * Watery tumor diathesis <br><br> |
| − | + | |}} | |
| − | Metastatic ovarian adenocarcinoma – C02-N42569 | + | {{collapsed| |
| + | Metastatic ovarian adenocarcinoma – C02-N42569| | ||
* Papillary architecture | * Papillary architecture | ||
* Nuclear enlargement | * Nuclear enlargement | ||
* Crowding | * Crowding | ||
* Loss of polarity | * Loss of polarity | ||
| − | * Psammoma bodies may be present | + | * Psammoma bodies may be present <br><br> |
| + | |}} | ||
Latest revision as of 15:05, June 23, 2020
Contents
Week 1
- Content Expert: David C. Wilbur, MD
- Cytotechnologist: Peter Brown
- Objective: To describe the common morphologic features in glandular cell lesions found in pap smears.
Related PDFs of Lectures
Normal endocervicals – MG07-41719
- Column cells with basally located nuclei
- Basophilic vacuolated cytoplasm
- Picket fence arrangement when seen on side, honeycomb when seen from above
- Nuclei round, oval, slightly larger than em nuclei, similar to sq. met.
Normal endometrial cells – MG07-37747
- Nuclei small, round, dark, indistinct nucleoli
- Cytoplasm is scant, may have vacuoles
- Deep stromal cells, dark, degenerate with scant cytoplasm
- Superficial stromal cells look like histocytes
- 3-D ball like clusters
Reactive endocervicals – C02-X21800
- Slightly to moderately enlarged nuclear size
- Prominent nucleoli
- Can see multinucleation
- Chromatin normal
- Nuclear contours regular
- In groups cells maintain polarity
Endocervical atypia 10D –C92-1561 and MG09-21470
- Changes are seen in endometrial cells or endocervical cells, em’s shed at mid cycle
- Single cells or small clusters of reaction endocervicals
- Normal or slightly irregular ems with vacuoles
- Actinomyces
Tubal metaplasia – G11-37675
- Single ec’s cells, strips of ec’s with pseudostratification or in clusters with either terminal bars or cilia
- Nuclei can be round or oval
- Slightly coarse chromatin (without the presence of cilia or terminal bars can be mistaken for AIS)
AIS endocervical – MG06-00971 and C01-D39098
- Columnar cells in crowded groups, strips on rosettes
- Strips may have pseudostratification, groups with irregular polarity
- Peripheral nuclear palisading (feathering)
- Irregular dark chromatin, nuclear enlargement
Endocervial Adenoca – MG09-31908
- Ec’s with enlarged hyperchromatic nuclei in strips
- Rosettes, pseudostratification, feathering
- Loss of polarity
- Difficult to differentiate from AIS
Endocervical Adenoca – C98-17153
- Strips, rosettes, feathering
- Disorderly arrangement
- High N/C ratio
- Coarse chromatin
- Architectural features similar to AIS but with greater loss of polarity
- Prominent nucleoli
- Mitosis
- Diasisis
Endometrial CA Grade III – C02-R1948
- Ball like and papillary groups of irregular glandular cells
- Nuclear contour irregularities
- Prominent nucleoli
- Watery tumor diathesis
Metastatic ovarian adenocarcinoma – C02-N42569
- Papillary architecture
- Nuclear enlargement
- Crowding
- Loss of polarity
- Psammoma bodies may be present
