Difference between revisions of "DZI19-121-Case-3"

From MGH Learn Pathology
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{{dziSlide
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{{ServiceRequestCase
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|order_date=September 11, 2019 01:57:48 PM
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|identifier=DZI19-121-Case-3
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|user=Em99
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|basedOn=DZI19-121
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|slide_stain=IDH1R132H
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|supportingInfo=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
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{{dziSlide
 
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|order_date=September 11, 2019 01:57:48 PM
 
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|qctime=Sep 13, 2019 20:41:00
 
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|order_date=September 11, 2019 01:57:48 PM
 
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|user=Em99
 
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|dziorder=DZI19-121
 
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|case_id=3
 
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|clinical_hx=45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
 
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|case_diagnosis=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
 
  
 
Histological diagnosis: Anaplastic astrocytoma (recurrent)
 
Histological diagnosis: Anaplastic astrocytoma (recurrent)
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ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
 
CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
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|order_date=September 14, 2019 01:35:40 AM
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}}

Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-3
45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT

Histological diagnosis: Anaplastic astrocytoma (recurrent)

WHO histological grade: III

Molecular information: IDH: MUTANT (R132H immunohistochemistry) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)

CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
December 31, 1969 7:00:00 PM







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