Difference between revisions of "DZI19-121-Case-2"

From MGH Learn Pathology
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|order_date=September 11, 2019 01:57:40 PM
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|supportingInfo=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
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|clinical_hx=32 yo woman with 2 weeks of headaches and mild nausea when changing head position
 
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|case_diagnosis=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
 
  
 
Histological diagnosis: anaplastic gemistocytic astrocytoma  
 
Histological diagnosis: anaplastic gemistocytic astrocytoma  
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ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 
MGMT promoter: methylated (methylation specific PCR)
 
MGMT promoter: methylated (methylation specific PCR)
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|media_text=MRI: axial, T1 post gadolinium, shows an expansile right frontal lobe mass with focal enhancement
 
 
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Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-2
32 yo woman with 2 weeks of headaches and mild nausea when changing head position
Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT

Histological diagnosis: anaplastic gemistocytic astrocytoma

WHO histological grade: III

Molecular information: IDH: mutant (R132H, IDH1/2 PCR sequencing) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)

MGMT promoter: methylated (methylation specific PCR)
December 31, 1969 7:00:00 PM







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