Difference between revisions of "DZI19-121-Case-1"

From MGH Learn Pathology
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{{dziSlide
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{{ServiceRequestCase
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|order_date=September 11, 2019 01:57:23 PM
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|identifier=DZI19-121-Case-1
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|user=Em99
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|intent=order
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|slide_stain=H&E
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|category=409073007
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|slide_anatomy=Show
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|priority=routine
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}}
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|orderDetail=case
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{{dziCase
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|locationCode=learn
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|qc=yes
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|basedOn=DZI19-121
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|qcuser=Em99
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|code=faculty
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|qctime=Sep 13, 2019 20:41:00
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|supportingInfo=Integrated diagnosis: GLIOBLASTOMA, IDH-WILDTYPE
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|order_date=September 11, 2019 01:57:23 PM
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|user=Em99
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Histological diagnosis: Glioblastoma
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|dziorder=DZI19-121
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|case_id=1
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WHO histological grade: IV
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|publish_timestamp=2019/09/13 19:00
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|clinical_hx=63 year old woman with a history of breast CA s/p bilateral mastectomy presents with difficulty walking, staggering gait, and fatigue
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Molecular information:
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|case_diagnosis=Glioblastoma, IDH-wildtype, WHO grade IV
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IDH1: negative (R132H immunohistochemistry)
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MGMT promoter: methylated (methylation specific PCR)
  
 
IHC for mutant ID1(R132H) was negative and is sufficient in patients >55 years of age to determine IDH status (rare to find non-canonical mutations in this group).
 
IHC for mutant ID1(R132H) was negative and is sufficient in patients >55 years of age to determine IDH status (rare to find non-canonical mutations in this group).
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|gross=[[File:Case 1.png|thumb|MRI: T1 coronal post gadolinium shows a large mass with irregular peripheral contrast enhancement]]
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|reasonCode=63 year old woman with a history of breast CA s/p bilateral mastectomy presents with difficulty walking, staggering gait, and fatigue
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|subject=MGH
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|performer=MML55
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|authoredOn=September 11, 2019 01:57:23 PM
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|requester=Em99
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|sequence=1
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|access=public
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}}
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{{Media
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|basedOn=DZI19-121-Case-1
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|type=image
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|view=show
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|partOf=DZI19-121
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|frames=1
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|reasonCode=H&E
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|identifier=DZI19-121-Case-1_1
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|createdDateTime=September 11, 2019 01:57:23 PM
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|operator=Em99
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|modality=ndpi
 
}}
 
}}
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{{dziMedia
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{{status
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|order_date=September 13, 2019 05:44:47 PM
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|status=active
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|user=Em99
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|requester=Em99
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|media_filename=Case_1.png
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|authoredOn=September 11, 2019 01:57:23 PM
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|media_text=MRI: T1 coronal post gadolinium shows a large mass with irregular peripheral contrast enhancement
 
 
}}
 
}}

Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-1
63 year old woman with a history of breast CA s/p bilateral mastectomy presents with difficulty walking, staggering gait, and fatigue
Integrated diagnosis: GLIOBLASTOMA, IDH-WILDTYPE

Histological diagnosis: Glioblastoma

WHO histological grade: IV

Molecular information: IDH1: negative (R132H immunohistochemistry) MGMT promoter: methylated (methylation specific PCR)

IHC for mutant ID1(R132H) was negative and is sufficient in patients >55 years of age to determine IDH status (rare to find non-canonical mutations in this group).
December 31, 1969 7:00:00 PM






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