Difference between revisions of "DZI19-121-Case-3"

From MGH Learn Pathology
(Edited automatically from page DZI19-121.)
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|order_date=September 11, 2019 01:57:48 PM
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|identifier=DZI19-121-Case-3
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|supportingInfo=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
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Histological diagnosis: Anaplastic astrocytoma (recurrent)
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WHO histological grade: III
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Molecular information:
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IDH: MUTANT (R132H immunohistochemistry)
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P53: positive in most tumor cells (immunohistochemistry, consistent with mutation)
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ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
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CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
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|reasonCode=45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
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|authoredOn=September 11, 2019 01:57:48 PM
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|clinical_hx=45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
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Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-3
45 year old man with a history of a “brain tumor” 10 years ago, now with headache and vision changes
Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT

Histological diagnosis: Anaplastic astrocytoma (recurrent)

WHO histological grade: III

Molecular information: IDH: MUTANT (R132H immunohistochemistry) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)

CDKN2A/B: homozygous deletion PRESENT (NGS sequencing)
December 31, 1969 7:00:00 PM







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