Difference between revisions of "DZI19-121-Case-2"

From MGH Learn Pathology
(Added status template)
 
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{{dziSlide
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{{ServiceRequestCase
|order_date=September 11, 2019 01:57:40 PM
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|identifier=DZI19-121-Case-2
|user=Em99
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|intent=order
|slide_anatomy=Show
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|category=409073007
 +
|priority=routine
 +
|orderDetail=case
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|locationCode=learn
 +
|basedOn=DZI19-121
 +
|code=faculty
 +
|supportingInfo=Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT
 +
 
 +
Histological diagnosis: anaplastic gemistocytic astrocytoma
 +
 
 +
WHO histological grade: III
 +
 
 +
Molecular information:
 +
IDH: mutant (R132H, IDH1/2 PCR sequencing)
 +
P53: positive in most tumor cells (immunohistochemistry, consistent with mutation)
 +
ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)
 +
MGMT promoter: methylated (methylation specific PCR)
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|reasonCode=32 yo woman with 2 weeks of headaches and mild nausea when changing head position
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|subject=MGH
 +
|performer=MML55
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|authoredOn=September 11, 2019 01:57:40 PM
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|requester=Em99
 +
|sequence=2
 +
|access=public
 
}}
 
}}
{{dziSlide
+
{{Media
|order_date=September 11, 2019 01:57:40 PM
+
|basedOn=DZI19-121-Case-2
|user=Em99
+
|type=image
|slide_anatomy=Show
+
|view=show
 +
|partOf=DZI19-121
 +
|frames=1
 +
|reasonCode=H&E
 +
|identifier=DZI19-121-Case-2_1
 +
|createdDateTime=September 11, 2019 01:57:40 PM
 +
|operator=Em99
 +
|modality=ndpi
 
}}
 
}}
{{dziSlide
+
{{Media
|order_date=September 11, 2019 01:57:40 PM
+
|basedOn=DZI19-121-Case-2
|user=Em99
+
|type=image
|slide_anatomy=Show
+
|view=show
 +
|partOf=DZI19-121
 +
|frames=2
 +
|reasonCode=ATRX
 +
|identifier=DZI19-121-Case-2_2
 +
|createdDateTime=September 11, 2019 01:57:40 PM
 +
|operator=Em99
 +
|modality=ndpi
 
}}
 
}}
{{dziCase
+
{{Media
|order_date=September 11, 2019 01:57:40 PM
+
|basedOn=DZI19-121-Case-2
|user=Em99
+
|type=image
|dziorder=DZI19-121
+
|view=show
|case_id=2
+
|partOf=DZI19-121
|clinical_hx=[[File:MRI case 2.png|thumb|MRI, axial, T1 post gadolinium, shows an expansile right frontal lobe mass with focal enhancement]]
+
|frames=3
32 yo female with 2 weeks of headaches and mild nausea when changing head position
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|reasonCode=p53
 +
|identifier=DZI19-121-Case-2_3
 +
|createdDateTime=September 11, 2019 01:57:40 PM
 +
|operator=Em99
 +
|modality=ndpi
 +
}}
 +
{{status
 +
|status=active
 +
|requester=Em99
 +
|authoredOn=September 11, 2019 01:57:40 PM
 
}}
 
}}

Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-2
32 yo woman with 2 weeks of headaches and mild nausea when changing head position
Integrated diagnosis: ANAPLASTIC ASTROCYTOMA, IDH-MUTANT

Histological diagnosis: anaplastic gemistocytic astrocytoma

WHO histological grade: III

Molecular information: IDH: mutant (R132H, IDH1/2 PCR sequencing) P53: positive in most tumor cells (immunohistochemistry, consistent with mutation) ATRX: nuclear expression lost (immunohistochemistry, consistent with mutation)

MGMT promoter: methylated (methylation specific PCR)
December 31, 1969 7:00:00 PM