Difference between revisions of "DZI19-121-Case-7"

From MGH Learn Pathology
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{{dziSlide
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{{ServiceRequestCase
|order_date=September 11, 2019 01:58:15 PM
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|identifier=DZI19-121-Case-7
|user=Em99
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|intent=order
|slide_anatomy=Show
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|category=409073007
 +
|priority=routine
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|orderDetail=case
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|locationCode=learn
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|basedOn=DZI19-121
 +
|code=faculty
 +
|supportingInfo=Integrated diagnosis:
 +
DIFFUSE GLIOMA, BRAF V600E-MUTANT
 +
 
 +
Histological diagnosis: Diffuse astrocytoma
 +
 
 +
WHO (integrated histological and molecular) grade: undefined (likely II)
 +
 
 +
Molecular information:
 +
BRAF V600E: MUTANT (immunohistochemistry and sequencing)
 +
IDH: wildtype (IDH1/2 sequencing)
 +
P53: weak in rare tumor cells (immunohistochemistry, consistent with wildtype)
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ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype)
 +
MGMT promoter: methylated (PCR)
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EGFR gene amplification: absent (FISH)
 +
|reasonCode=23 year old woman with deep left cerebellar mass discovered incidentally on an MRI of the cervical spine obtained after a motor vehicle accident.
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|subject=MGH
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|performer=MML55
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|authoredOn=September 11, 2019 01:58:15 PM
 +
|requester=Em99
 +
|sequence=7
 +
|access=public
 
}}
 
}}
{{dziSlide
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{{Media
|order_date=September 11, 2019 01:58:15 PM
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|basedOn=DZI19-121-Case-7
|user=Em99
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|type=image
|slide_anatomy=Show
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|view=show
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|partOf=DZI19-121
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|frames=1
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|reasonCode=H&E
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|identifier=DZI19-121-Case-7_1
 +
|createdDateTime=September 11, 2019 01:58:15 PM
 +
|operator=Em99
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|modality=ndpi
 
}}
 
}}
{{dziCase
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{{Media
|order_date=September 11, 2019 01:58:15 PM
+
|basedOn=DZI19-121-Case-7
|user=Em99
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|type=image
|dziorder=DZI19-121
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|view=show
|case_id=7
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|partOf=DZI19-121
|clinical_hx=23 year old woman with deep left cerebellar mass discovered incidentally on an MR view of the cervical spine obtained after a motor vehicle accident.
+
|frames=2
 +
|reasonCode=MUTANT BRAF V600E
 +
|identifier=DZI19-121-Case-7_2
 +
|createdDateTime=September 11, 2019 01:58:15 PM
 +
|operator=Em99
 +
|modality=ndpi
 +
}}
 +
{{status
 +
|status=active
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|requester=Em99
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|authoredOn=September 11, 2019 01:58:15 PM
 
}}
 
}}

Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-7
23 year old woman with deep left cerebellar mass discovered incidentally on an MRI of the cervical spine obtained after a motor vehicle accident.
Integrated diagnosis:

DIFFUSE GLIOMA, BRAF V600E-MUTANT

Histological diagnosis: Diffuse astrocytoma

WHO (integrated histological and molecular) grade: undefined (likely II)

Molecular information: BRAF V600E: MUTANT (immunohistochemistry and sequencing) IDH: wildtype (IDH1/2 sequencing) P53: weak in rare tumor cells (immunohistochemistry, consistent with wildtype) ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype) MGMT promoter: methylated (PCR)

EGFR gene amplification: absent (FISH)
December 31, 1969 7:00:00 PM