Difference between revisions of "DZI19-121-Case-5"

From MGH Learn Pathology
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|identifier=DZI19-121-Case-5
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|supportingInfo=Integrated diagnosis:
 +
DIFFUSE MIDLINE GLIOMA, H3K27M-MUTANT
 +
 
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Histological diagnosis: Anaplastic astrocytoma
 +
 
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WHO (integrated histological and molecular) grade: IV
 +
 
 +
Molecular information:
 +
H3K27M: MUTANT (immunohistochemistry)
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IDH: wildtype (IDH1/2 PCR sequencing)
 +
P53: negative in tumor cells (immunohistochemistry, consistent with wildtype)
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ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype)
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MGMT promoter: unmethylated (methylation specific PCR)
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|reasonCode=38 y.o. woman with a 2 month hx of positional vertigo, L facial weakness, tinnitus, and left anterior tongue numbness
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|subject=MGH
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|performer=MML55
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|authoredOn=September 11, 2019 01:58:00 PM
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Latest revision as of 13:23, December 9, 2024

DZI19-121-Case-5
38 y.o. woman with a 2 month hx of positional vertigo, L facial weakness, tinnitus, and left anterior tongue numbness
Integrated diagnosis:

DIFFUSE MIDLINE GLIOMA, H3K27M-MUTANT

Histological diagnosis: Anaplastic astrocytoma

WHO (integrated histological and molecular) grade: IV

Molecular information: H3K27M: MUTANT (immunohistochemistry) IDH: wildtype (IDH1/2 PCR sequencing) P53: negative in tumor cells (immunohistochemistry, consistent with wildtype) ATRX: nuclear expression retained (immunohistochemistry, consistent with wildtype)

MGMT promoter: unmethylated (methylation specific PCR)
December 31, 1969 7:00:00 PM