WSI24-485: Gastrointestinal didactic - Tuesday, July 21, 2026

From MGH Learn Pathology


Request type AP didactic (409073007) - BWH
Subspecialty Gastrointestinal
Set [[]]
Topic Liver _ Steatotic liver disease
Presenter Zhao, Lei,MD, PhD
Date and time Tuesday, July 21, 2026 1:00 PM



Case Clinical history Requester
Case Clinical history Requester

Case 1


48-year-old woman with history of breast cancer (2022 diagnosis status post resection and chemotherapy finished 2024 currently on Lupron/Letrozole) diabetes BMI 30 pulmonary valve stenosis and no alcohol use since 2022 presenting with abnormal liver enzymes and abnormal liver imaging. Most recent labs (Apr2026) showed AST 32 ALT 29 Alk Phos 147 tBili 0.5 albumin 4.6 and globulin 3.2 as well as normal ANA A1 antitrypsin and mitochondrial M2 Ab. Portal pressure gradient was calculated as 16 mm Hg (consistent with CSPH with highest HV pressure of 10mmHg and lowest PV pressure of 25mmHg) by EUS. Liver stiffness by EUS elastography ~7kPa left liver ~13 kPa right liver. Also found small (<5mm) esophageal varices. Lz31