-Marked lymphocytic thyroiditis with extensive lymphoplasmacytic infiltrate, follicular atrophy, and with multiple nodules present within fibroadipose tissue and lipomatous metaplasia, with a dominant adenomatous nodule measuring at least 1.6 cm, consistent with end-stage Hashimoto's thyroiditis within the appropriate clinical setting.
Immunohistochemistry performed at MGH on block C2 shows that the residual thyroid follicles within the inflammatory infiltrate are positive for TTF-1, PAX 8, very focally positive for thyroglobulin, and are negative for p63, and p40. S100 highlights the sustentacular cells and is negative within the follicular cells.
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Clinical history
38F Right Thyroid Nodule
Diagnosis
C. RIGHT HEMITHYROID: -Marked lymphocytic thyroiditis with extensive lymphoplasmacytic infiltrate, follicular atrophy, and with multiple nodules present within fibroadipose tissue and lipomatous metaplasia, with a dominant adenomatous nodule measuring at least 1.6 cm, consistent with end-stage Hashimoto's thyroiditis within the appropriate clinical setting. Immunohistochemistry performed at MGH on block C2 shows that the residual thyroid follicles within the inflammatory infiltrate are positive for TTF-1, PAX 8, very focally positive for thyroglobulin, and are negative for p63, and p40. S100 highlights the sustentacular cells and is negative within the follicular cells.
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