B. PANCREAS HEAD CYSTIC MASS CORE BIOPSY: Adenocarcinoma. Note: Mucinous epithelium is present around and focally invasive of sclerotic stroma. Immunostains show the following profile: P53- wild-type staining, SMAD4- wild-type staining, P16- loss of nuclear staining supporting a mutation.
C. PANCREAS HEAD CYST FLUID: NEOPLASTIC: OTHER- Mucinous cyst with high-grade features, at least high-grade dysplasia.
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Clinical history
80 yo M w/ pancreas cyst
Diagnosis
A. FINE NEEDLE ASPIRATION BIOPSY, PANCREAS HEAD CYSTIC MASS: Adenocarcinoma associated with a high-grade papillary mucinous neoplasm. B. PANCREAS HEAD CYSTIC MASS CORE BIOPSY: Adenocarcinoma. Note: Mucinous epithelium is present around and focally invasive of sclerotic stroma. Immunostains show the following profile: P53- wild-type staining, SMAD4- wild-type staining, P16- loss of nuclear staining supporting a mutation. C. PANCREAS HEAD CYST FLUID: NEOPLASTIC: OTHER- Mucinous cyst with high-grade features, at least high-grade dysplasia.
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