WSI21-139: Lymph Nodes

From MGH Learn Pathology


Request type Study
Subspecialty Cytology
Set Cytology
Topic Lymph Nodes
Presenter MGH
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Toggle columns: Diagnosis

Case Clinical history Requester Diagnosis
Case Clinical history Requester Diagnosis

Case 1


82F. Right neck lymphadenopathy. Level IV lymph node FNA. Iac0 Metastatic papillary thyroid carcinoma.

Case 2


52M. Left inguinal lymph node FNA. Iac0 Acute neutrophilic necrotizing lymphadenitis secondary to syphilis infection.

Case 3


74 y/old M with CLL and clinical suspicion for fungemia Lcm51 Cryptococcus. Small mature lymphocytes consistent with CLL.

Case 4


Lytic appearing osseous lesion and omental lesion (this sample) Lcm51 Low grade B cell lymphoma (Follicular Lymphoma)

Case 5


History of testicular mass. Iac0 Metastatic seminoma.

Case 6


69 year old M with new lymphadenopathy. Aja51 Mantle cell lymphoma

Case 7


83 y/old F with superior mediastinum mass associated with cervical and thoracic lymphadenopathy Aja51 Diffuse Large B cell lymphoma germinal center type.

Case 8


77F. Cervical lymphadenopathy Iac0 Diffuse large B-cell lymphoma.

Case 9


43yo M with supraclavicular lymphadenopathy Mlz8 EBV-positive DLBCL

Case 10


80 y/old M with multiple enlarged LNs on the upper chest and neck. Lcm51 Mantle cell lymphoma (CD20/CD5 positive flow cytometry)

Case 11


65 y/old M with sclerotic bone lesions splenomegaly IGA monoclonal spike malaise and lymphadenopathy Lcm51 Diffuse Castleman's disease plasma cell variant (patient has POEMS syndrome)

Case 12


77 YO female with an enlarged right neck lymph node Ndk6 B-cell lymphoma with medium-to-large cells

Case 13


78 YO female with h/o grade 1 follicular lymphoma. Enlarged right inguinal lymph node. Ndk6 Consistent with involvement by lymphoma

Case 14


78 YO female with h/o melanoma and new enlarged axillary lymph node Ndk6 Metastatic melanoma

Case 15


70 yo F with cardiac tamponade and retroperitoneal lymphadenopathy. Cfh13 Atypical. Polymorphous lymphoid population including atypical large cells against a background of abundant histiocytes. Concurrent core biopsy: Consistent with peripheral T-Cell lymphoma with T-cell follicular helper phenotype.

Case 16


hx of Li-Fraumeni syndrome- IDC grade 3 poorly differentiated adrenal cortical carcinoma leiomyosarcoma now with enlarged lymph nodes including left axillary lymph node Imaging showed a rupture left breast implant Est105 reactive changes consistent with a rupture implant

Case 17


79 yo M with a history of DLBCL on treatment with new retroperitoneal lymphadenopathy. Cfh13 Positive for malignant cells. Morphologically consistent with diffuse large B-cell lymphoma.

Case 18


18 yo F with abdominal pain and a new pelvic nodule. Cfh13 Positive for Malignant Cells. Anaplastic Large T-cell lymphoma.

Case 19


60 yo F with diffuse abdominal lymphadenopathy. Cfh13 Diffuse large B-cell lymphoma (DLBCL)

Case 20


63 yo man with a prominent neck node and no known prior malignancies Cfh13 Metastatic melanoma

Case 21


61 yo woman with cervical lymphadenopathy Cfh13 No malignant cells identified.

Polymorphous lymphocytes consistent with reactive lymph node.

Prominent lymphoglandular bodies.

Case 22


74 yo F with enlarging left superior mediastinal lymph node. History of breast and uterine ca. Ndk6 Metastatic adenocarcinoma consistent with breast primary

Case 23


29M enlarged left axillary lymph node Mlz8 Classic Hodgkin lymphoma mixed cellularity type

Case 24


73M enlarged right axillary lymph node Mlz8 Reactive follicular hyperplasia

Case 25


76 yo F with enlarged supraclavicular lymph node Ndk6 POSITIVE FOR MALIGNANT CELLS.

- Metastatic carcinoma with features suggestive of squamous cell carcinoma

- Atypical lymphoid population consistent with involvement by the patient's known chronic lymphocytic leukemia.

Case 26


64 yo F Ndk6 POSITIVE FOR MALIGNANT CELLS - Consistent with the patient's known high-grade B-cell lymphoma.

Case 27


10 yo M with several months of cervical lymphadenopathy up to 3 cm. Cfh13 No malignant cells identified. Polymorphous lymphocytes with reactive germinal centers and prominent emperipolesis. Note: The findings are overall consistent with a reactive lymph node; however the emperipolesis raises the possibility of Rosai-Dorfman disease.

Case 28


25 yo female Dc679 Hodgkin Lymphoma

Case 29


90 yo male with enlarged right cervical lymph node Ndk6 Metastatic melanoma

Case 139


76 yo f with h/o NSCLC and lymphoma with enlarging FDG avid R SCV LN Ndk6 Metastatic adenocarcinoma

Case 140


33M mediastinal mass. Hilar lymphadenopathy. Iac0 Hodgkin lymphoma.