Warthin tumor (see comment). Comment: The small core biopsy shows columnar-lined oxyphilic epithelium with underlying lymphoid tissue composed predominantly of small lymphocytes with rare small reactive appearing germinal centers. Immunohistochemical stains show that the underlying lymphocytic infiltrate is composed of aggregates of CD20+, CD5- B cells with intervening CD3+ CD5+ T cell rich regions. BCL2 stains most lymphocytes with a rare small germinal centers negative for BCL2. Flow cytometry is negative for a B cell lymphoproliferative disorder (see below).
The findings support a diagnosis of Warthin tumor.
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Clinical history
48 yo male
Diagnosis
A. INTRAPAROTID LYMPH NODE BX RIGHT: Warthin tumor (see comment). Comment: The small core biopsy shows columnar-lined oxyphilic epithelium with underlying lymphoid tissue composed predominantly of small lymphocytes with rare small reactive appearing germinal centers. Immunohistochemical stains show that the underlying lymphocytic infiltrate is composed of aggregates of CD20+, CD5- B cells with intervening CD3+ CD5+ T cell rich regions. BCL2 stains most lymphocytes with a rare small germinal centers negative for BCL2. Flow cytometry is negative for a B cell lymphoproliferative disorder (see below). The findings support a diagnosis of Warthin tumor.
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